Evidence map›Paper›PMID 36101779›Full record

ArticleInternational journal of hematologic oncology2022

Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia.

Guray Saydam, Ali Unal, Ibrahim Celalettin Haznedaroglu, Abdullah Hacihanifioglu, Ozgur Mehtap, Erdal Kurtoglu, Mesut Gocer, Mehmet Turgut, Engin Kelkitli, Memis Hilmi Atay and 18 more

Abstract read
In one paragraph

Article in International journal of hematologic oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Guray SaydamDepartment of Internal Diseases, Division of Hematology, Ege University Medical Faculty Hospital, Izmir, 35100, Turkey.ORCID https://orcid.org/0000-0001-8646-1673
Ali UnalDepartment of Internal Diseases, Division of Hematology, Erciyes University Faculty of Medicine, Kayseri, 38030, Turkey.ORCID https://orcid.org/0000-0001-7011-3412
Ibrahim Celalettin HaznedarogluDepartment of Internal Diseases, Division of Hematology, Hacettepe University Faculty of Medicine, Ankara, 06230, Turkey.ORCID https://orcid.org/0000-0001-8028-9462
Abdullah HacihanifiogluDepartment of Internal Diseases, Division of Hematology, Kocaeli University Faculty of Medicine, Izmit, 41001, Turkey.ORCID https://orcid.org/0000-0001-5164-6301
Ozgur MehtapDepartment of Internal Diseases, Division of Hematology, Kocaeli University Faculty of Medicine, Izmit, 41001, Turkey.ORCID https://orcid.org/0000-0002-5603-1178
Erdal KurtogluDepartment of Internal Diseases, Division of Hematology, University of Health Sciences, Antalya Training & Research Hospital, Antalya, 07100, Turkey.ORCID https://orcid.org/0000-0002-6867-6053
Mesut GocerDepartment of Internal Diseases, Division of Hematology, University of Health Sciences, Antalya Training & Research Hospital, Antalya, 07100, Turkey.ORCID https://orcid.org/0000-0002-0346-7154
Mehmet TurgutDepartment of Internal Diseases, Division of Hematology, Ondokuz Mayis University Faculty of Medicine, Samsun, 55139, Turkey.ORCID https://orcid.org/0000-0002-1036-0232
Engin KelkitliDepartment of Internal Diseases, Division of Hematology, Ondokuz Mayis University Faculty of Medicine, Samsun, 55139, Turkey.ORCID https://orcid.org/0000-0001-7342-1760
Memis Hilmi AtayDepartment of Internal Diseases, Division of Hematology, Ondokuz Mayis University Faculty of Medicine, Samsun, 55139, Turkey.ORCID https://orcid.org/0000-0001-9666-6955
Nil GulerDepartment of Internal Diseases, Pamukkale University Faculty of Medicine, Denizli, 20160, Turkey.ORCID https://orcid.org/0000-0003-0604-6475
Basak Unver KolumanDepartment of Internal Diseases, Pamukkale University Faculty of Medicine, Denizli, 20160, Turkey.ORCID https://orcid.org/0000-0003-1106-5021
Mehmet SonmezDepartment of Internal Diseases, Division of Hematology, Karadeniz Technical University Faculty of Medicine, Trabzon, 61080, Turkey.ORCID https://orcid.org/0000-0002-2176-4371
Nergiz ErkutDepartment of Internal Diseases, Division of Hematology, Karadeniz Technical University Faculty of Medicine, Trabzon, 61080, Turkey.ORCID https://orcid.org/0000-0002-6683-0432
Emin KayaDepartment of Internal Diseases, Division of Hematology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey.ORCID https://orcid.org/0000-0001-8605-8497
Irfan KukuDepartment of Internal Diseases, Division of Hematology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey.ORCID https://orcid.org/0000-0001-6126-0816
Mehmet Ali ErkurtDepartment of Internal Diseases, Division of Hematology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey.ORCID https://orcid.org/0000-0002-3285-417X
Gulsum OzetDepartment of Hematology, Ankara City Hospital, Ankara, 06800, Turkey.ORCID https://orcid.org/0000-0003-2658-5978
Funda CeranDepartment of Hematology, Ankara City Hospital, Ankara, 06800, Turkey.ORCID https://orcid.org/0000-0003-3173-7614
Fahri SahinDepartment of Internal Diseases, Division of Hematology, Ege University Medical Faculty Hospital, Izmir, 35100, Turkey.ORCID https://orcid.org/0000-0001-9315-8891
Nur SoyerDepartment of Internal Diseases, Division of Hematology, Ege University Medical Faculty Hospital, Izmir, 35100, Turkey.ORCID https://orcid.org/0000-0002-7722-506X
Meliha NalcaciDepartment of Internal Diseases, Istanbul University Istanbul Faculty of Medicine, Istanbul, 34093, Turkey.ORCID https://orcid.org/0000-0002-2555-5024
Mehmet YilmazDepartment of Internal Diseases, Division of Hematology, SANKO University Faculty of Medicine, Gaziantep, 27090, Turkey.ORCID https://orcid.org/0000-0002-1218-8165
Sirac BozkurtDepartment of Medical Oncology, Pfizer Pharmaceuticals, Istanbul, 34394, Turkey.ORCID https://orcid.org/0000-0003-4053-8174
Birkan AverDepartment of Medical Oncology, Pfizer Pharmaceuticals, Istanbul, 34394, Turkey.ORCID https://orcid.org/0000-0002-8650-6883
Begum OzdengulsunDepartment of Medical Oncology, Pfizer Pharmaceuticals, Istanbul, 34394, Turkey.ORCID https://orcid.org/0000-0001-8751-6664
Egemen OzbilgiliDepartment of Medical Oncology, Pfizer Pharmaceuticals, Istanbul, 34394, Turkey.ORCID https://orcid.org/0000-0002-0403-1432
Osman IlhanDepartment of Internal Diseases, Division of Hematology, Ankara University Faculty of Medicine, Ankara, 06230, Turkey.ORCID https://orcid.org/0000-0003-1665-372X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aimed to identify patient characteristics, treatment patterns and outcomes and to evaluate the effects of presence of comorbidities at diagnosis in chronic phase (CP)-chronic myeloid leukemia (CML) patients in Turkey. Materials & methods: Hospital records between 2005 and 2018 were retrospectively reviewed. Results: Of 861 CP-CML patients included, 31% had at least one comorbidity at diagnosis. Sex, cardiovascular disease status at diagnosis and molecular (at least major) and cytogenetic (partial and complete) responses were the independent predictors of survival. Conclusion: The response rates of CP-CML patients to the tyrosine kinase inhibitors were satisfactory. In addition to tolerability and side effect profiles of drugs, comorbidity status of patients should also be considered in treatment choice in CML patients.

Indexed as

chronic myeloid leukemiaco-medication usecomorbiditycytogenetic responsehematologic responsemolecular responsesurvivaltyrosine kinase inhibitors

Identifiers

PMID36101779
PMCPMC9453544

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.