ArticleNeurology. Genetics2022
High Hereditary Transthyretin-Related Amyloidosis Prevalence in Crete: Genetic Heterogeneity and Distinct Phenotypes.
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Article in Neurology. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- Primary oculoleptomeningeal transthyretin amyloidosis with subarachnoid hemorrhages, visual loss, and heart and skin amyloid deposits.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Mutant p.Val114Ala Transthyretin-Related Cardiac Amyloidosis with Heart Failure and Right Bundle Branch Block.Anatolian journal of cardiology · 2025Article
- Epidemiology of Pediatric Cardiomyopathy in a Mediterranean Population.Children (Basel, Switzerland) · 2024Article
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18 authors at 4 institutions in 1 country.
Minas TzagournissakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Emmanouil FoukarakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Dimitrios SamonakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Miltiadis TsilimbarisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Kleita MichaelidouNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Lambros MathioudakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Anastasios MarinisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Emmanouil GiannakoudakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Cleanthe SpanakiNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Irene SkoulaNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Sofia ErimakiNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Georgios AmoiridisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Georgios KoutsisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Sofia KoukourakiNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Kostas StylianouNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Andreas PlaitakisNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Panayiotis D MitsiasNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
Ioannis ZaganasNeurology Department (M. Tzagournissakis, C.S., S.E., P.D.M., I.Z.), University Hospital of Heraklion; Cardiology Department (E.F.), Venizelion General Hospital of Heraklion; Gastroenterology Department (D.S.), and Ophthalmology Department (M. Tsilimbaris), University Hospital of Heraklion; Neurogenetics Laboratory (K.M., L.M., A.M., I.S., G.A., A.P., I.Z.), Medical School, University of Crete, Heraklion; Neurology Department (E.G.), Venizelion General Hospital of Heraklion, Crete; Eginition Hospital (G.K.), Medical School, University of Athens; Nuclear Medicine Department (S.K.), University Hospital of Heraklion; and Renal Medicine Department (K.S.), University Hospital of Heraklion, Crete, Greece.
The General Hospital of Heraklion "Venizeleio-Pananio" · GREginition Hospital · GRNational and Kapodistrian University of Athens · GRUniversity Hospital of Heraklion · GR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Our goal was to study hereditary transthyretin-related amyloidosis (hATTR) in Crete, Greece. Methods: We aimed at ascertaining all hATTR cases in Crete, an island of 0.62 million people. For this, we evaluated patients with polyneuropathy, autonomic involvement, cardiomyopathy, and/or ophthalmopathy suggestive of hATTR, who presented to the physicians of this study or were referred to them by other physicians. Genetic analyses were performed on all patients suspected of suffering from hATTR. We included in our observational longitudinal cohort study all individuals, residents of Crete, who, during the study period (1993-2019), were found to carry a pathogenic Results: Over the past 27 years, 30 individuals (15 female patients, 15 male patients), from 12 apparently unrelated families, were diagnosed with hATTR, whereas evaluation of their offspring identified 5 asymptomatic Discussion: Our study revealed that the prevalence of hATTR in Crete is one of the world's highest. Three different pathogenic
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