Evidence map›Paper›PMID 36101432›Full record

ArticleBiology2022

Cardiovascular Stress and Characteristics of Cold-Induced Vasodilation in Women and Men during Cold-Water Immersion: A Randomized Control Study.

Lydia Tsoutsoubi, Leonidas G Ioannou, Konstantinos Mantzios, Styliani Ziaka, Lars Nybo, Andreas D Flouris

Abstract read
In one paragraph

Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026
    Review
  3. Influence of body dimensions and sex on cold-induced vasodilation.European journal of applied physiology · 2025
    Article
  4. Cold-induced vasodilation during sequential immersions of the hand.European journal of applied physiology · 2024
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lydia TsoutsoubiFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.ORCID 0000-0002-5093-1458
Leonidas G IoannouFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.ORCID 0000-0001-5460-8167
Konstantinos MantziosFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.ORCID 0000-0002-1740-9748
Styliani ZiakaFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.ORCID 0000-0002-1004-8134
Lars NyboDepartment of Nutrition, Exercise and Sports, August Krogh Building, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-9090-1958
Andreas D FlourisFAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.ORCID 0000-0002-9823-3915

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCold-induced vasodilation (CIVD) is a phenomenon that refers to a paradoxical increase in finger temperature that sometimes occurs during cold exposure. The aim of this study was to compare CIVD responses between women and men, during exposure to different environmental conditions.

methodsSeven men and seven women participated in a matched controlled study consisting of a familiarization protocol followed by three experimental sessions (cool (10.8 °C WBGT), thermoneutral (17.2 °C WBGT), and hot (27.2 °C WBGT)). In each session, participants were asked to immerse their left hand and foot in warm water (35 ± 1 °C) for five minutes. Thereafter, the left hand and foot were immersed in cold water (8 ± 1 °C) for 40 min. After that, the left hand and foot were removed from the water and participants remained seated for five minutes.

resultsFor a matched thermal stress, women experienced an elevated cardiovascular strain (heart rate and in some cases mean arterial pressure) and higher frequency of CIVD reactions (men: 31 vs. women: 60) in comparison to their male counterparts.

conclusionsThe present study demonstrated that women experienced elevated cardiovascular strain and higher frequency of CIVD reactions, particularly in the toes, compared to their male counterparts during cold-water immersion.

Indexed as

CIVDcore temperaturegenderheart ratemean arterial pressurepainsexskin temperaturesweat ratewater immersion

Identifiers

PMID36101432
PMCPMC9312820

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.