Evidence map›Paper›PMID 36100939›Full record

ArticleBMC cancer2022

The effect of Nrf

Omid Cheraghi, Bahareh Dabirmanesh, Farideh Ghazi, Massoud Amanlou, Mona Atabakhshi-Kashi, Yaghoub Fathollahi, Khosro Khajeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Omid CheraghiDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Iran.
Bahareh DabirmaneshDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Iran. dabirmanesh@modares.ac.ir.
Farideh GhaziDepartment of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Massoud AmanlouDepartment of Medical Chemistry, Faculty of Pharmacy and Pharmaceutical Science, Tehran, Iran.
Mona Atabakhshi-KashiCAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Yaghoub FathollahiDepartment of Medical Physiology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Khosro KhajehDepartment of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, P.O. Box: 14115-175, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer is one of the most common cancer and the third leading cause of death worldwide. Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Several studies have reported that an increase in ROS production could affect the expression of proteins involved in ROS-scavenging, detoxification and drug resistance. Nuclear factor erythroid 2 related factor 2 (Nrf

methodsThe influence of chemotherapy drugs (doxorubicin and cisplatin), metastasis and cell viability were investigated. To explore the association between specific pathways and viability in HT29-Nrf

resultsIn the absence of Nrf

conclusionsOur results revealed MAPKs, JNK and FOXO pathways connections in reducing the deleterious effect of Nrf

Indexed as

Colorectal NeoplasmsProteomicsCell LineHumansOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesMAPK pathwayMitochondriaNrf2Proteomics

Identifiers

PMID36100939
PMCPMC9472369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.