Evidence map›Paper›PMID 36100920›Full record

ArticleParticle and fibre toxicology2022

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study.

Shotaro Yamano, Yuko Goto, Tomoki Takeda, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Tatsuya Kasai, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Subchronic Inhalation of TiOJournal of applied toxicology : JAT · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Biomedical application of TiOCell biology and toxicology · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Titanium Dioxide Nanoparticles Altered the lncRNA Expression Profile in Human Lung Cells.International journal of environmental research and public health · 2023
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Shotaro YamanoJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan. shotaro-yamano@pulmpath.com.
Yuko Goto *Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Tomoki Takeda *Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Shigeyuki HiraiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Yusuke FurukawaJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Yoshinori KikuchiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Tatsuya KasaiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Kyohei MisumiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Masaaki SuzukiJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Kenji TakanobuJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Hideki SenohJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Misae SaitoJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Hitomi KondoJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan.
Yumi UmedaJapan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Hadano, Kanagawa, 257-0015, Japan. yumi-umeda@jbrc.johas.go.jp.
Japan Organization of Occupational Health and Safety · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost toxicological studies on titanium dioxide (TiO

methodsMale and female F344 rats were exposed to 6.3, 12.5, 25, or 50 mg/m

resultsNumerous milky white spots were present in the lungs after exposure to 25 and 50 mg/m

conclusionsInhalation exposure to TiO

Indexed as

Lung DiseasesNanoparticlesPneumoconiosisAnimalsDustEndothelial CellsFemaleLungMaleMammalsRatsRats, Inbred F344TitaniumDustTitaniumtitanium dioxideF344 ratPulmonary dust foci (PDF)Rat pneumoconiosisTitanium dioxide nanoparticles (TiO2 NPs)Whole-body inhalation

Identifiers

PMID36100920
PMCPMC9472424
OpenAlexW4295751782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.