ArticleCardiovascular diabetology2022
Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Combined effects of cumulative triglyceride-glucose and blood pressure on stroke in middle-aged and older Chinese adults: a longitudinal analysis.Journal of global health · 2026Article
- Dynamic Changes in Triglyceride Glucose‒Waist‒to‒Height Ratio and the Risk of Major Adverse Cardiovascular Events: Role of Concurrent Mean Arterial Pressure Change.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Comparative associations of cumulative cholesterol-HDL-glucose index and triglyceride-glucose index with risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study.Lipids in health and disease · 2025Article
- Joint association of TyG index and LDL-C with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease.Scientific reports · 2025Article
- Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients.Scientific reports · 2025Article
- Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease.International urology and nephrology · 2024Article
- Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population.Cardiovascular diabetology · 2024Article
- Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation.Journal of geriatric cardiology : JGC · 2024Article
- Predictors of In-Stent Stenosis Following the Implantation of Pipeline Embolization Devices for the Treatment of Aneurysms Located at or beyond the Circle of Willis in the Anterior Circulation.AJNR. American journal of neuroradiology · 2024Article
- Predictive Value of Triglyceride-Glucose Index for All-Cause and Cardiovascular Mortality in Patients With Diabetes Mellitus: A Retrospective Study: TyG Index and Mortality in Diabetes.International journal of endocrinology · 2024Article
- Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study.Cardiovascular diabetology · 2023Article
- Triglyceride glucose index as a predictor of mortality in middle-aged and elderly patients with type 2 diabetes in the US.Scientific reports · 2023Article
- An innovative model for predicting coronary heart disease using triglyceride-glucose index: a machine learning-based cohort study.Cardiovascular diabetology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFuture risk of cardiovascular disease (CVD) and mortality is associated with cumulative amount TyG index (cumTyG) exposure, while whether time course of TyG accumulation modulates the risk remains unclear. This study sought to examine the associations of cumTyG index accumulation time course with the risk of CVD and all-cause mortality.
methodsWe enrolled 51,734 participants free of CVD and underwent three examinations at year 2006, 2008, and 2010. CumTyG from baseline to the third examination was calculated. Time course of cumTyG accumulation was calculated as the slope of TyG versus time from 2006 to 2010, or as splinting the overall TyG index accumulation into early (cumTyG
resultsDuring a median follow-up of 9.04 years, we identified 3,602 incident CVD cases and 3,165 deaths. The risk of CVD and all-cause mortality increased with decreased TyG slope, the corresponding adjusted hazard ratio (aHR) with 95% confidence interval (CI) was 1.11 (1.04-1.19) and 1.18 (1.10-1.26) for patients with a negative TyG slope, respectively. Consistently, a later accumulation of TyG index was not associated with the risk of CVD and all-cause mortality after adjustment for an early accumulation. When considering the combination of cumTyG index and time course, participants with a cumTyG ≥ median and a negative TyG slope had elevated risk of CVD (aHR, 1.37; 95% CI, 1.24-1.51) and all-cause mortality (aHR, 1.28; 95% CI, 1.15-1.43). Additionally, the association was more prominent in young adults.
conclusionEarly TyG index accumulation resulted in a greater risk of CVD and all-cause mortality than later TyG later accumulation with the same overall cumulative exposure, emphasizing the importance of optimal TyG index control earlier in life.
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