Evidence map›Paper›PMID 36100822›Full record

ArticleBiological trace element research2023

Arsenic Activates the NLRP3 Inflammasome and Disturbs the Th1/Th2/Th17/Treg Balance in the Hippocampus in Mice.

Hui Jing, Nan Yan, Ronghua Fan, Zhou Li, Qian Wang, Kangjie Xu, Xinkang Hu, Lifeng Zhang, Xiaoxu Duan

Abstract read
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In one paragraph

Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hui Jing *Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Nan Yan *Department of Medical Applied Technology, Shenyang Medical College, Shenyang, 110034, China.
Ronghua FanDepartment of Health Inspection, College of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Zhou LiDepartment of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Qian WangDepartment of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Kangjie XuDepartment of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Xinkang HuClinical Medicine ("5+3" integrated Training), The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Lifeng ZhangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, Shenyang, 110034, China. zgykdxzlf@163.com.
Xiaoxu DuanDepartment of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, 110034, China. duanxiaoxu@symc.edu.cn.
Shenyang Medical College · CNChina Medical University · CN

Funding

Liaoning Province Key Research and Development Program Guidance Plan No. 2019JH8/10300047National Natural Science Foundation of China No. 81803180 and No. 81803200Science and Technology Innovation Fund of Shenyang Medical College No. Y20210513Shenyang Middleyounger Scientific and Technological Innovation Support Plan No. RC190479 and No. RC200238Shenyang Science and technology plan project social governance science and technology special project No. 21-108-9-11the Basic Research Project of Liaoning Provincial Department of Education Youth Project No. LJKQZ2021173
6 · The paper itself

Abstract

Arsenic exerts neurotoxicity and immunomodulatory effects. Studies have shown that the nervous system is not considered to be an immune-privileged site. However, the effect of arsenic-induced neuroimmune toxicity has rarely been reported. We aimed to investigate the toxic effects of arsenic on the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and the Th1/Th2/Th17/Treg balance in the brain tissue of mice. Mice were exposed to NaAsO

Indexed as

ArsenicInflammasomesAnimalsCytokinesHippocampusMiceNLR Family, Pyrin Domain-Containing 3 ProteinRNA, MessengerT-Lymphocytes, RegulatoryArsenicCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseRNA, MessengerArsenicHippocampusNeuroimmuneNLRP3 inflammasomeT lymphocyte

Identifiers

PMID36100822
OpenAlexW4295528243

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.