Evidence map›Paper›PMID 36100730›Full record

ArticleJournal of neurology2023

Postural instability in Parkinson's disease assessed with clinical "pull test" and standardized postural perturbations: effect of medication and body weight support.

Chiahao Lu, Kenneth H Louie, Amber M Stutz, Colum D MacKinnon, Scott E Cooper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chiahao LuDepartment of Neurology, University of Minnesota, 516E. 717 Delaware Building. 717 Delaware St. SE, Minneapolis, MN, 55414, USA. luxxx214@umn.edu.ORCID http://orcid.org/0000-0002-6356-7253
Kenneth H LouieDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, 55414, USA.
Amber M StutzDepartment of Neurology, University of Minnesota, 516E. 717 Delaware Building. 717 Delaware St. SE, Minneapolis, MN, 55414, USA.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, 516E. 717 Delaware Building. 717 Delaware St. SE, Minneapolis, MN, 55414, USA.
Scott E CooperDepartment of Neurology, University of Minnesota, 516E. 717 Delaware Building. 717 Delaware St. SE, Minneapolis, MN, 55414, USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2021 to 2025
$11.3M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseR01NS124814 · NINDS · UNIVERSITY OF MINNESOTA · PI SCOTT E COOPER · 2022 to 2026
$3.7M
Predictors of progression to freezing of gait in Parkinson's diseaseR01NS088679 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2015 to 2018
$1.6M
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS088679NINDS NIH HHS R01 NS124814NINDS NIH HHS R01 NS124814-01A1
6 · The paper itself

Abstract

objectiveThis experiment tested if balance performance differed between a standardized treadmill surface perturbation task and a clinical pull test and was affected by medication or the presence of body weight support in people with Parkinson's disease (PD).

methodsTwenty-seven individuals were tested (14 PD in both ON- and OFF-medication states). Clinical pull test and rapid forward (backward fall) translations of the support surface were applied to induce postural reactions requiring at least 1 step to restore balance. The effects of pull type (clinical vs. treadmill), partial bodyweight support (0 vs 20% body weight) and group (control, PD ON-meds and PD OFF-meds) on reactive stepping as well as practice/learning effect were examined. The number of steps taken and the first step duration were entered in linear repeated-measures mixed-effect models separately.

resultsThe effects of pull type, group, and bodyweight support were all significant in both metrics, as was ON- vs. OFF-medication. A significant interaction term (group x pull type) was found in the first step duration, showing that the group difference was greater in treadmill compared to the clinical pull test. A significant practice effect was also observed within and across testing sessions.

conclusionsA standardized treadmill perturbation performed slightly better than the classical pull test in distinguishing between groups, and partial weight support did not substantially degrade the test's performance to detect the balance deficits in people with PD.

Indexed as

Parkinson DiseaseBody WeightHumansLearningPostural BalanceParkinson’s diseasePostural instabilityPostural perturbationPull testReactive stepping

Identifiers

PMID36100730
PMCPMC10204773
OpenAlexW4295761924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.