Evidence map›Paper›PMID 36100689›Full record

ArticleCommunications biology2022

Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics.

Nancy Aguilera, Tao Liu, Andrew J Bower, Joanne Li, Sarah Abouassali, Rongwen Lu, John Giannini, Maximilian Pfau, Chelsea Bender, Margery G Smelkinson and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

Nancy AguileraNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0863-596X
Tao LiuNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9864-3896
Andrew J BowerNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1645-5950
Joanne LiNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2845-2490
Sarah AbouassaliNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Rongwen LuNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
John GianniniNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7626-6540
Maximilian PfauNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Chelsea BenderNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Margery G SmelkinsonNational Institute of Allergy and Infectious Disease, Research Technologies Branch, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7777-5574
Amelia NaikNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Bin GuanNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Owen SchwartzNational Institute of Allergy and Infectious Disease, Research Technologies Branch, National Institutes of Health, Bethesda, MD, USA.
Andrei VolkovNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Alfredo DubraDepartment of Ophthalmology, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-6506-9020
Zhuolin LiuDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA.
Daniel X HammerDivision of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0003-0532-1914
Dragan MaricNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2912-7921
Robert FarissNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Robert B HufnagelNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Brett G JeffreyNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9549-0644
Brian P BrooksNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Wadih M ZeinNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Laryssa A HurynNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Johnny TamNational Eye Institute, National Institutes of Health, Bethesda, MD, USA. johnny@nih.gov.ORCID http://orcid.org/0000-0003-2300-0567
National Institutes of Health · USCenter for Devices and Radiological Health · USStanford University · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Increasing the isoplanatic patch in adaptive optics ophthalmoscopyR01EY032147 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2025
$2.4M
Improving rigor and reproducibility in adaptive optics ophthalmoscopyR01EY031360 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2020 to 2023
$2.3M
Low Latency Eye-Motion CompensationR01EY032669 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2021 to 2024
$1.8M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY031360NEI NIH HHS R01 EY032147NEI NIH HHS R01 EY032669
6 · The paper itself

Abstract

Choroideremia is an X-linked, blinding retinal degeneration with progressive loss of photoreceptors, retinal pigment epithelial (RPE) cells, and choriocapillaris. To study the extent to which these layers are disrupted in affected males and female carriers, we performed multimodal adaptive optics imaging to better visualize the in vivo pathogenesis of choroideremia in the living human eye. We demonstrate the presence of subclinical, widespread enlarged RPE cells present in all subjects imaged. In the fovea, the last area to be affected in choroideremia, we found greater disruption to the RPE than to either the photoreceptor or choriocapillaris layers. The unexpected finding of patches of photoreceptors that were fluorescently-labeled, but structurally and functionally normal, suggests that the RPE blood barrier function may be altered in choroideremia. Finally, we introduce a strategy for detecting enlarged cells using conventional ophthalmic imaging instrumentation. These findings establish that there is subclinical polymegathism of RPE cells in choroideremia.

Indexed as

ChoroideremiaRetinal DegenerationChoroidFemaleHumansMaleOptics and PhotonicsRetinal Cone Photoreceptor Cells

Identifiers

PMID36100689
PMCPMC9470576
OpenAlexW4295347171

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.