ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023
Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.Gut microbes · 2026Review
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Article
- From Self-Esteem to Symptoms: A Potential Role for Difficulties Accessing Internal States and Body-Checking Behavior in Disordered Eating Patterns.Behavioral sciences (Basel, Switzerland) · 2026Article
- The role of the caudate nucleus in taste function: a comprehensive narrative review.Frontiers in neuroscience · 2026Review
- Addressing Altered Anticipation as a Transdiagnostic Target Through Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Review
- Exploring the role of the amygdala in Compulsive Sexual Behavior Disorder via a parcellation pipeline based on Recurrence Quantification Analysis.Journal of behavioral addictions · 2025Article
- Article
- Weight gained during treatment predicts 6-month body mass index in a large sample of patients with anorexia nervosa using ensemble machine learning.The International journal of eating disorders · 2024Article
- Eating Disorders: Updates and Innovations.Focus (American Psychiatric Publishing) · 2024Article
- Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders.Focus (American Psychiatric Publishing) · 2024Article
- Neural Response to Expecting a Caloric Sweet Taste Stimulus Predicts Body Mass Index Longitudinally Among Young Adult Women With Anorexia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- What influences food choices in anorexia nervosa? Disentangling cognitive and emotional components of decision-making by translational research.Neuroscience applied · 2024Review
- Therapeutic ketogenic diet as treatment for anorexia nervosa.Frontiers in nutrition · 2024Review
- Depression, anxiety, and stress in medical students in Peru: a cross-sectional study.Frontiers in psychiatry · 2023Article
- Anticipatory and consummatory pleasure in eating disorders.Journal of eating disorders · 2022Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Anxious traits are elevated in eating disorders (EDs), are considered risk factors for ED development, and trait anxiety has been linked to ED psychopathology. How trait anxiety relates to ED neurobiology is not well understood. In this study 197 individuals across the ED spectrum (anorexia nervosa n = 91; other specified EDs n = 34; bulimia nervosa n = 56; binge ED n = 16), and 120 healthy controls were assessed for anxious traits and learned to expect and receive caloric or neutral taste stimuli during brain imaging. Amygdala sucrose expectation response differed across groups (Wilk's lambda = 0.945, p = 0.023), and was higher on the left in anorexia nervosa compared to healthy controls (p = 0.002). Expected sucrose receipt response across taste reward regions was not different between groups. In the ED sample, trait anxiety negatively moderated the relationship between amygdala expectation and right dorsal (p = 0.0062) and ventral (p = 0.0046) anterior insula receipt response. A subgroup analysis showed similar results for anorexia nervosa, and partially in bulimia nervosa. Across EDs, appetitive motivation correlated positively with bilateral orbitofrontal cortex, caudate head, and ventral striatal sucrose receipt response (r = 0.215 to 0.179, p = 0.002 to 0.012). Across the study sample, trait anxiety showed an inverted-U-shaped relationship with right (r = 0.147, p = 0.034) and left (r = 0.162, p = 0.016) amygdala expectation response. Amygdala sucrose expectation response is elevated in anorexia nervosa, correlates with sucrose receipt response, and this relationship is negatively moderated by trait anxiety across EDs. Trait anxiety may have an important role in how expectation drives taste stimulus receipt brain response and perhaps food approach in individuals with EDs.
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Registered trials
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