Evidence map›Paper›PMID 36100641›Full record

ArticleLeukemia2022

Is unmeasurable residual disease (uMRD) the best surrogate endpoint for clinical trials, regulatory approvals and therapy decisions in chronic lymphocytic leukaemia (CLL)?

Shenmiao Yang, Neil E Kay, Min Shi, Curtis A Hanson, Robert Peter Gale

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Shenmiao YangPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing, China.ORCID http://orcid.org/0000-0001-7261-8449
Neil E KayMayo Clinic, Department of Medicine, Division of Hematology, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5951-5055
Min ShiMayo Clinic, Department of Laboratory Medicine and Pathology, Division of Hematopathology, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5741-4293
Curtis A HansonMayo Clinic, Department of Laboratory Medicine and Pathology, Division of Hematopathology, Rochester, MN, USA.
Robert Peter GaleHaematology Research Centre, Department of Immunology and Inflammation, Imperial College of Science, Technology and Medicine, London, UK. robertpetergale@alumni.ucla.edu.ORCID http://orcid.org/0000-0002-9156-1676
Mayo Clinic in Arizona · USImperial College London · GBPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellAntineoplastic Combined Chemotherapy ProtocolsBiomarkersHumansNeoplasm, ResidualBiomarkers

Identifiers

PMID36100641
OpenAlexW4295757909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.