ArticleBMJ open diabetes research & care2022
Comprehensive validation of fasting-based and oral glucose tolerance test-based indices of insulin secretion against gold standard measures.
Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses.BMJ open diabetes research & care · 2024Pooled it
- Acute ingestion of snake fruit jelly improves glycemic response, enhances endurance performance and antioxidant defense, and reduces inflammatory markers in healthy adults.Journal of the International Society of Sports Nutrition · 2025Trial
- Measuring the Impact of Data Quality and Computable Phenotypes on Potential Racial Disparities in Predicting Healthcare Utilization Among Type 2 Diabetes Populations.Journal of racial and ethnic health disparities · 2026Article
- Postprandial Glucagon Action in the Human Brain.Diabetes, obesity & metabolism · 2026Article
- Coregulated metabolite networks associated with global protein crotonylation are central pathophysiological processes in prediabetes and diabetes.medRxiv : the preprint server for health sciences · 2026Article
- Beyond Glucose-Rethinking Prediabetes for Precision Prevention.Diabetes care · 2026Review
- Relevance of Quantitative Measures of Beta-Cell Function in Clinical Practice.Hormone research in paediatrics · 2026Review
- Association between islet β-cell function and time in range in patients with type 2 diabetes mellitus: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Observational
- Metabolic heterogeneity at the onset of type 2 diabetes: phenotypes of insulin resistance and β-cell function in the Kazakh population.Frontiers in endocrinology · 2026Article
- Mildly elevated liver lipid content is characterised by reduced insulin sensitivity.JHEP reports : innovation in hepatology · 2025Article
- Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test.Journal of the Endocrine Society · 2025Article
- Association of triglyceride-glucose-body mass index with all-cause mortality among individuals with cardiovascular disease: results from NHANES.Frontiers in endocrinology · 2025Article
- Relationship between all-cause mortality and triglyceride-glucose-body mass index in elderly patients with intravenous thrombolysis for acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2025Article
- Non-Linear Relationship Between Fasting C-Peptide and Retinopathy in Patients with Type 2 Diabetes Mellitus - A Retrospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Impact of Physiological Fluctuations of Sex Hormones During the Menstrual Cycle on Glucose Metabolism and the Gut Microbiota.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024Review
- A prospective guide for clinical implementation of selected OGTT- derived surrogate indices for the evaluation of β- cell function and insulin sensitivity in patients with transfusion-dependent β- thalassaemia.Acta bio-medica : Atenei Parmensis · 2023Article
- Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations.Acta diabetologica · 2023Article
- Sex-Specific Models to Predict Insulin Secretion and Sensitivity in Subjects with Overweight and Obesity.International journal of molecular sciences · 2023Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWith pre-diabetes and diabetes increasingly recognized as heterogeneous conditions, assessment of beta-cell function is gaining clinical importance to identify disease subphenotypes. Our study aims to comprehensively validate all types of surrogate indices based on oral glucose tolerance test (OGTT) and fasting measurements in comparison with gold standard methods. RESEARCH DESIGN AND
methodsThe hyperglycemic clamp extended with glucagon-like peptide 1 (GLP-1) infusion and intravenous glucose tolerance test (IVGTT), as well as OGTT, was performed in two well-phenotyped cohorts. The gold standard-derived indices were compared with surrogate insulin secretion markers, derived from fasting state and OGTT, using both Pearson's and Spearman's correlation coefficients. The insulin-based and C-peptide-based indices were analyzed separately in different groups of glucose tolerance and the entire cohorts.
resultsThe highest correlation coefficients were found for area under curve (AUC) (I
conclusionsWe have identified glucose-stimulated and GLP-1-stimulated insulin secretion indices, derived from OGTT and fasting state, that have the strongest correlation with gold standard measures and could be potentially used in future researches and clinical practice.
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