Evidence map›Paper›PMID 36099905›Full record

ArticleDevelopmental cell2022

A limb bud morphogen bites the dust.

Hyunji Lee, Steven A Vokes

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hyunji LeeDepartment of Molecular Biosciences, University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX 78712, USA.
Steven A VokesDepartment of Molecular Biosciences, University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX 78712, USA. Electronic address: svokes@austin.utexas.edu.

Funding

Cis-regulatory circuitry underlying Hedgehog mediated limb developmentR01HD073151 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Steven Alexander Vokes · 2012 to 2026
$5.1M
NICHD NIH HHS R01 HD073151
6 · The paper itself

Abstract

Hedgehog signaling has traditionally been considered to be a morphogen for digits. In this issue of Developmental Cell, Zhu et al. show that a brief exposure to Sonic Hedgehog is sufficient for digit specification, and this finding suggests that it is not acting as a direct morphogen but rather as an initiator of this process.

Indexed as

Hedgehog ProteinsLimb BudsBody PatterningDustGene Expression Regulation, DevelopmentalDustHedgehog Proteins

Identifiers

PMID36099905
PMCPMC9477441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.