Evidence map›Paper›PMID 36099315›Full record

ArticlePLoS computational biology2022

In the Body's Eye: The computational anatomy of interoceptive inference.

Micah Allen, Andrew Levy, Thomas Parr, Karl J Friston

Abstract read
In one paragraph

Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. A Theoretical Framework for Studying the Phenomenon of Gaslighting.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026
    Review
  6. Article
  7. Echoes of Pregnancy: Maternal Perception of Phantom Fetal Movements After Childbirth.BJOG : an international journal of obstetrics and gynaecology · 2026
    Observational
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Moving from isolation to integration: a Bayesian multisensory perspective of interoception and psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  18. Article
  19. Metacognitive Feelings: A Predictive-Processing Perspective.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
    Review
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Micah AllenCentre of Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark.ORCID 0000-0001-9399-4179
Andrew LevyWellcome Centre for Human Neuroimaging, University College London, London, United Kingdom.
Thomas ParrWellcome Centre for Human Neuroimaging, University College London, London, United Kingdom.
Karl J FristonWellcome Centre for Human Neuroimaging, University College London, London, United Kingdom.ORCID 0000-0001-7984-8909

Funding

Wellcome TrustWellcome Trust 088130/Z/09/Z
6 · The paper itself

Abstract

A growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in cognitive science. However, thus far no formal theory has emerged to integrate these twin domains; instead, most extant work is conceptual in nature. Here, we introduce a formal model of cardiac active inference, which explains how ascending cardiac signals entrain exteroceptive sensory perception and uncertainty. Through simulated psychophysics, we reproduce the defensive startle reflex and commonly reported effects linking the cardiac cycle to affective behaviour. We further show that simulated 'interoceptive lesions' blunt affective expectations, induce psychosomatic hallucinations, and exacerbate biases in perceptual uncertainty. Through synthetic heart-rate variability analyses, we illustrate how the balance of arousal-priors and visceral prediction errors produces idiosyncratic patterns of physiological reactivity. Our model thus offers a roadmap for computationally phenotyping disordered brain-body interaction.

Indexed as

InteroceptionBrainEmotionsHeart Rate

Identifiers

PMID36099315
PMCPMC9506608

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.