Evidence map›Paper›PMID 36099298›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in

Ke-Jung Huang, Homer Pantua, Jingyu Diao, Elizabeth Skippington, Michael Volny, Wendy Sandoval, Varnesh Tiku, Yutian Peng, Meredith Sagolla, Donghong Yan and 9 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
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  9. Review
  10. The BfmRS stress response protectsJournal of bacteriology · 2025
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ke-Jung HuangDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.
Homer PantuaDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.ORCID 0000-0001-6460-2623
Jingyu DiaoDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.
Elizabeth SkippingtonDepartment of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases Bioinformatics, Genentech, South San Francisco, CA 94080.
Michael VolnyDepartment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080.
Wendy SandovalDepartment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080.
Varnesh TikuDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.
Yutian PengDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.
Meredith SagollaDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Donghong YanDepartment of Translational Immunology, Genentech, South San Francisco, CA 94080.ORCID 0000-0001-7686-2756
Jing KangDepartment of Translational Immunology, Genentech, South San Francisco, CA 94080.
Anand Kumar KatakamDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Nairie MichaelianDepartment of Structural Biology, Genentech, South San Francisco, CA 94080.ORCID 0000-0003-1605-1788
Mike ReicheltDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Man-Wah TanDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.ORCID 0000-0002-7748-212X
Cary D AustinDepartment of Pathology, Genentech, South San Francisco, CA 94080.ORCID 0000-0002-5388-7413
Min XuDepartment of Translational Immunology, Genentech, South San Francisco, CA 94080.ORCID 0000-0002-0121-7397
Emily HananDepartment of Chemistry, Genentech, South San Francisco, CA 94080.ORCID 0000-0001-7681-9424
Sharookh B KapadiaDepartment of Infectious Diseases, Genentech, South San Francisco, CA 94080.ORCID 0000-0002-6301-3111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsAspartic Acid EndopeptidasesBacterial ProteinsDrug Resistance, BacterialFuransGene DeletionLipoproteinsProtease InhibitorsPyridinesPeptidesProtein Sorting Signals7-fluoro-3-(2-fluoro-4-iodophenylamino)-N-(2-hydroxypropoxy)furo(3,2-c)pyridine-2-carboxamideAnti-Bacterial AgentsAspartic Acid EndopeptidasesBacterial ProteinsFuransglobomycinLipoproteinsPeptidesProtease InhibitorsProtein Sorting SignalsPyridinessignal peptidase IIAcinetobacter baumanniiantibiotic resistanceglobomycinLspA

Identifiers

PMID36099298
PMCPMC9499571
OpenAlexW4295502607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.