Evidence map›Paper›PMID 36099295›Full record

ArticlePloS one2022

COVID-19 vaccine acceptance and perceived risk among pregnant and non-pregnant adults in Cameroon, Africa.

Nuwan Gunawardhana, Kendall Baecher, Alexander Boutwell, Seraphine Pekwarake, Mirabelle Kifem, Mary Glory Ngong, Anthony Fondzeyuf, Gregory Halle-Ekane, Rahel Mbah, Pius Tih and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Nuwan GunawardhanaDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Kendall BaecherSchool of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.ORCID 0000-0002-9292-167X
Alexander BoutwellDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Seraphine PekwarakeCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Mirabelle KifemCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Mary Glory NgongCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Anthony FondzeyufCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Gregory Halle-EkaneDepartment of Obstetrics and Gynecology, University of Buea, Buea, Cameroon.
Rahel MbahCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Pius TihCameroon Health Initiative at the University of Alabama at Birmingham (CHI UAB), Birmingham, Alabama, United States of America.
Jodie Dionne-OdomDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Denis M TebitDepartment of Microbiology, University of Venda, Thohoyandou, South Africa.ORCID 0000-0002-4540-6245
University of Alabama at Birmingham · USUniversity of Buea · CMUniversity of Venda · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe public health response to the global COVID-19 pandemic has varied widely by region. In Africa, uptake of effective COVID-19 vaccines has been limited by accessibility and vaccine hesitancy. The aim of this study was to compare perceptions of COVID-19 infection and vaccination between pregnant women and non-pregnant adults in four regions of Cameroon, located in Central Africa.

methodsA cross-sectional survey study was conducted at urban and suburban hospital facilities in Cameroon. Participants were randomly selected from a convenience sample of adult pregnant and non-pregnant adults in outpatient clinical settings between June 1st and July 14th, 2021. A confidential survey was administered in person by trained research nurses after obtaining written informed consent. Participants were asked about self-reported sociodemographics, medical comorbidities, perceptions of COVID-19 infection, and vaccination. Descriptive statistics were used for survey responses and univariate and multivariable logistic regression models were created to explore factors associated with COVID-19 vaccine acceptability.

resultsFewer than one-third of participants were interested in receiving the COVID-19 vaccine (31%, 257/835) and rates did not differ by pregnancy status. Overall, 43% of participants doubted vaccine efficacy, and 85% stated that the vaccine available in Africa was less effective than vaccine available in Europe. Factors independently associated with vaccine acceptability included having children (aOR = 1.5; p = 0.04) and higher education (aOR = 1.6 for secondary school vs primary/none; p = 0.03). Perceived risks of vaccination ranged from death (33%) to fetal harm (31%) to genetic changes (1%). Health care professionals were cited as the most trusted source for health information (82%, n = 681).

conclusionCOVID-19 vaccine hesitancy and misinformation in Cameroon was highly prevalent among pregnant and non-pregnant adults in 2021 while vaccine was available but not recommended for use in pregnancy. Based on study findings, consistent public health messaging from medical professionals about vaccine safety and efficacy and local production of vaccine are likely to improve acceptability.

Indexed as

COVID-19Influenza VaccinesAdultCameroonCOVID-19 VaccinesCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHumansPandemicsPregnancySelf ReportCOVID-19 VaccinesInfluenza Vaccines

Identifiers

PMID36099295
PMCPMC9469991
OpenAlexW4295482869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.