Evidence map›Paper›PMID 36099159›Full record

ArticleInternational journal of epidemiology2023

Estimating the excess burden of pertussis disease in Australia within the first year of life, that might have been prevented through timely vaccination.

Duleepa Jayasundara, Deborah Randall, Sarah Sheridan, Vicky Sheppeard, Bette Liu, Peter C Richmond, Christopher C Blyth, James G Wood, Hannah C Moore, Peter B McIntyre and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Duleepa JayasundaraNSW Biostatistics Training Program, NSW Ministry of Health, St Leonards, NSW, Australia.
Deborah RandallWomen and Babies Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Sarah SheridanWomen and Babies Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Vicky SheppeardPublic Health Unit, South Eastern Sydney Local Health District, Sydney, NSW, Australia.
Bette LiuNational Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, NSW, Australia.
Peter C RichmondWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Christopher C BlythWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
James G WoodSchool of Population Health, UNSW Medicine, UNSW, Sydney, NSW, Australia.
Hannah C MooreWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Peter B McIntyreNational Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, Sydney, NSW, Australia.
Heather F GiddingWomen and Babies Research, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
University of Sydney · AUUNSW Sydney · AUNational Centre for Immunisation Research & Surveillance · AUNew South Wales Department of Health · AUNorthern Sydney Local Health District · AUPrincess Margaret Hospital for Children · AUThe Kids Research Institute Australia · AUUniversity of Otago · NZUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious Australian studies have shown that delayed vaccination with each of the three primary doses of diphtheria-tetanus-pertussis-containing vaccines (DTP) is up to 50 % in certain subpopulations. We estimated the excess burden of pertussis that might have been prevented if (i) all primary doses and (ii) each dose was given on time.

methodsPerinatal, immunization, pertussis notification and death data were probabilistically linked for 1 412 984 infants born in two Australian states in 2000-12. A DTP dose administered >15 days after the recommended age was considered delayed. We used Poisson regression models to compare pertussis notification rates to 1-year of age in infants with ≥1 dose delayed (Aim 1) or any individual dose delayed (Aim 2) versus a propensity weighted counterfactual on-time cohort.

resultsOf all infants, 42% had ≥1 delayed DTP dose. We estimated that between 39 to 365 days of age, 85 (95% CI: 61-109) cases per 100 000 infants, could have been prevented if all infants with ≥1 delayed dose had received their three doses within the on-time window. Risk of pertussis was higher in the delayed versus the on-time cohort, so crude rates overestimated the excess burden (110 cases per 100 000 infants (95% CI: 95-125)). The estimated dose-specific excess burden per 100 000 infants was 132 for DTP1, 50 for DTP2 and 19 for DTP3.

conclusionsWe provide robust evidence that improved DTP vaccine timeliness, especially for the first dose, substantially reduces the burden of infant pertussis. Our methodology, using a potential outcomes framework, is applicable to other settings.

Indexed as

Haemophilus VaccinesWhooping CoughAged, 80 and overAustraliaDiphtheria-Tetanus-Pertussis VaccineFemaleHumansInfantPregnancyVaccinationDiphtheria-Tetanus-Pertussis VaccineHaemophilus VaccinesPertussispropensity score weightingvaccination timeliness

Identifiers

PMID36099159
PMCPMC9908038
OpenAlexW4295423185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.