Evidence map›Paper›PMID 36099134›Full record

ArticleIn vivo (Athens, Greece)

The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.

Tetsuya Hyodo, Yoshiya Ito, Kanako Hosono, Satoshi Uematsu, Shizuo Akira, Masataka Majima, Akira Takeda, Hideki Amano

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tetsuya HyodoDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Yoshiya ItoDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Kanako HosonoDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Satoshi UematsuDepartment of Immunology and Genomics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Shizuo AkiraLaboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.
Masataka MajimaDepartment of Medical Therapeutics, Kanagawa Institute of Technology, Atsugi, Japan.
Akira TakedaDepartment of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Hideki AmanoDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan; hideki@med.kitasto-u.ac.jp.
Kitasato University · JPKanagawa Institute of Technology · JPOsaka City University · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMicrosomal prostaglandin E synthase-1 (mPGES-1) is an enzyme, which catalyzes the final step of prostaglandin E MATERIALS AND

methodsThe dorsal subcutaneous tissues of male mPGES-1-deficient (mPGES-1

resultsAngiogenesis was suppressed in mPGES-1

conclusionTregs producing TGFβ and VEGF accumulate in wounds and contribute to angiogenesis through mPGES-1-derived PGE

Indexed as

T-Lymphocytes, RegulatoryVascular Endothelial Growth Factor AAnimalsDinoprostoneForkhead Transcription FactorsGranulation TissueMaleMiceMice, Inbred C57BLNeovascularization, PathologicProstaglandin-E SynthasesTransforming Growth Factor betaDinoprostoneForkhead Transcription FactorsProstaglandin-E SynthasesPtges protein, mouseTransforming Growth Factor betaVascular Endothelial Growth Factor AangiogenesismPGES-1PGE2Tregswound

Identifiers

PMID36099134
PMCPMC9463939
OpenAlexW4294904027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.