Evidence map›Paper›PMID 36099118›Full record

ArticleIn vivo (Athens, Greece)

Antonino Amato, Gordon McVie, Giovanni Paganelli, Pier Luigi Carriero, Roberto Cianni, Giuseppe Maria Ettorre

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Antonino AmatoBetaGlue Technologies SpA, Milan, Italy; a.amato@betaglue.com.
Gordon McVieKing's College London, London, U.K.
Giovanni PaganelliIstituto Romagnolo Studio Tumori, IRCCS, Meldola, Italy.
Pier Luigi CarrieroBetaGlue Technologies SpA, Milan, Italy.
Roberto CianniSan Camillo/Forlanini Hospital, Rome, Italy.
Giuseppe Maria EttorreSan Camillo/Forlanini Hospital, Rome, Italy.
Carlo Forlanini Hospital · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimBAT-90 is an innovative active implantable device designed for the irradiation of unresectable tumors (e.g., liver cancer) or surgical tumor beds, based on the combination of Yttrium-90 beta-emitting microspheres and a tissue adhesive hydrogel, currently used in cardio-vascular surgery. The rationale behind BAT-90 is to localize the Yttrium-90 activity on the administration site, while minimizing its body dispersion. MATERIALS AND

methodsThe effective induction of necrosis in the target injection area was tested in a pig liver model, whereas the safety of BAT-90 was assessed and demonstrated in biocompatibility tests for acute systemic toxicity, intracutaneous reactivity, delayed hypersensitivity and subcutaneous implantation.

resultsBAT-90 administration induced necrosis into the target site, while the safety experiments in the treated animals highlighted results very similar to the controls.

conclusionBAT-90 could be considered as a safe and innovative treatment option for inoperable solid tumors of the liver.

Indexed as

Liver NeoplasmsYttrium RadioisotopesAnimalsMicrospheresNecrosisSwineYttrium-90Yttrium Radioisotopes90-YttriumInternal radiotherapyunresectable liver tumors

Identifiers

PMID36099118
PMCPMC9463933
OpenAlexW4294903846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.