ArticleJournal of clinical laboratory analysis2022
The influence of prostate volume on clinical parameters in prostate cancer screening.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Positive predictive value of the prostate imaging reporting and data system combined with single related indicators in prostate cancer across different prostate zones.Frontiers in oncology · 2026Article
- Effect of prostate volume on the predictive value of prostate-specific antigen density for prostate cancer.Translational andrology and urology · 2025Article
- Potential diagnostic value of multiple indicators combined with total prostate-specific antigen in prostate cancer.The Journal of international medical research · 2023Article
- The influence of prostate volume on clinical parameters in prostate cancer screening.Journal of clinical laboratory analysis · 2022Article
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Authors and funding
10 authors.
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Abstract
purposeThe purpose of the study was to evaluate the diagnostic significance of two new and a few clinical markers for prostate cancer (PCa) at various prostate volumes (PV).
methodsThe study subjects were divided into two groups. Among them, there were 70 cases in the PV ≤30 ml group (benign prostatic hyperplasia [BPH]: 32 cases, PCa: 38 cases) and 372 cases in the PV > 30 ml group (BPH: 277 cases, PCa: 95 cases). SPSS 26.0 and GraphPad Prism 8.0 were used to construct their receiver operating characteristic (ROC) curves for diagnosing PCa and calculating their area under the ROC curve (AUC).
resultsIn the PV ≤30 ml group, the diagnostic parameters based on prostate-specific antigen (PSA) had a decreased diagnostic significance for PCa. In the PV > 30 ml group, PSAD (AUC = 0.709), AVR (AVR = Age/PV, AUC = 0.742), and A-PSAD (A-PSAD = Age×PSA/PV, AUC = 0.736) exhibited moderate diagnostic significance for PCa, which was better than PSA-AV (AUC = 0.672), free PSA (FPSA, AUC = 0.509), total PSA (TPSA, AUC = 0.563), (F/T) PSA (AUC = 0.540), and (F/T)/PSAD (AUC = 0.663). Compared with AVR, A-PSAD exhibited similar diagnostic significance for PCa, but higher than PSA density (PSAD).
conclusionsChoosing appropriate indicators for different PVs could contribute to the early screening and diagnosis of PCa. The difference in the diagnostic value of two new indicators (A-PSAD and AVR), and PSAD for PCa may require further validation by increasing the sample size.
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