ArticleHuman brain mapping2022
Test-retest reliability of diffusion tensor imaging scalars in 5-year-olds.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Immune proteomic associations with indices of cortical development in 5-year-old children.Journal of anatomy · 2026Article
- Effortful Control and Cortical Brain Structure in 5-Year-Old Children: Findings From the FinnBrain Birth Cohort Study.The European journal of neuroscience · 2026Article
- A scoring model for differentiating gastric calcifying fibrous tumors from gastrointestinal stromal tumors less than 2 cm based on CT features.BMC medical imaging · 2026Article
- MICAFlow: Fast and robust MRI preprocessing bridging research neuroimaging and clinical practice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Cross-Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change.Human brain mapping · 2025Article
- Structural brain correlates of non-verbal cognitive ability in 5-year-old children: Findings from the FinnBrain birth cohort study.Human brain mapping · 2023Article
- Test-retest reliability of diffusion tensor imaging scalars in 5-year-olds.Human brain mapping · 2022Article
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13 authors.
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Abstract
Diffusion tensor imaging (DTI) has provided great insights into the microstructural features of the developing brain. However, DTI images are prone to several artifacts and the reliability of DTI scalars is of paramount importance for interpreting and generalizing the findings of DTI studies, especially in the younger population. In this study, we investigated the intrascan test-retest repeatability of four DTI scalars: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in 5-year-old children (N = 67) with two different data preprocessing approaches: a volume censoring pipeline and an outlier replacement pipeline. We applied a region of interest (ROI) and a voxelwise analysis after careful quality control, tensor fitting and tract-based spatial statistics. The data had three subsets and each subset included 31, 32, or 33 directions thus a total of 96 unique uniformly distributed diffusion encoding directions per subject. The repeatability of DTI scalars was evaluated with intraclass correlation coefficient (ICC(3,1)) and the variability between test and retest subsets. The results of both pipelines yielded good to excellent (ICC(3,1) > 0.75) reliability for most of the ROIs and an overall low variability (<10%). In the voxelwise analysis, FA and RD had higher ICC(3,1) values compared to AD and MD and the variability remained low (<12%) across all scalars. Our results suggest high intrascan repeatability in pediatric DTI and lend confidence to the use of the data in future cross-sectional and longitudinal studies.
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