Evidence map›Paper›PMID 36098213›Full record

ArticleJournal of cellular and molecular medicine2022

Hypercholesterolemia promotes autoantibody production and a lupus-like pathology via decreased DNase-mediated clearance of DNA.

Umesh Kumar Dhawan, Andreas Margraf, Maciej Lech, Manikandan Subramanian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Umesh Kumar DhawanCentre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andreas MargrafCentre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Maciej LechLMU Hospital Department of Medicine, Munich, Germany.ORCID 0000-0002-4293-2733
Manikandan SubramanianCentre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-2608-3890
Queen Mary University of London · GBLMU Klinikum · DE

Funding

Barts Charity, UK MGU0459Deutsche Forschungsgemeinschaft DFG MA 9604/1-1The Wellcome Trust DBT India Alliance IA/E/21/1/506321Wellcome Trust
6 · The paper itself

Abstract

Hypercholesterolemia exacerbates autoimmune response and accelerates the progression of several autoimmune disorders, but the mechanistic basis is not well understood. We recently demonstrated that hypercholesterolemia is associated with increased serum extracellular DNA levels secondary to a defect in DNase-mediated clearance of DNA. In this study, we tested whether the impaired DNase response plays a causal role in enhancing anti-nuclear antibody levels and renal immune complex deposition in an Apoe

Indexed as

Autoimmune DiseasesDeoxyribonucleasesHypercholesterolemiaLupus Erythematosus, SystemicAnimalsAntigen-Antibody ComplexAutoantibodiesDNAHumansMiceMice, Knockout, ApoEAntigen-Antibody ComplexAutoantibodiesDeoxyribonucleasesDNAautoantibodyautoimmunecholesterolDNaseextracellular DNA

Identifiers

PMID36098213
PMCPMC9575094
OpenAlexW4295408800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.