Evidence map›Paper›PMID 36098043›Full record

ArticleJournal of clinical laboratory analysis2022

Logistic regression models of cytokines in differentiating vitreoretinal lymphoma from uveitis.

Sha Tian, Kun Chen, Jianjiang Xiao, Xian Zhou, Huimin Shi, Yi Li, Hehe Huang, Yanchun Ma, Bobin Chen, Qingping Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sha TianDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5336-7573
Kun ChenDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jianjiang XiaoDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Xian ZhouDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Huimin ShiDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Yi LiDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Hehe HuangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Yanchun MaDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Bobin ChenDepartment of Hematology, Huashan Hospital, Fudan University, Shanghai, China.
Qingping WangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Ming GuanDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitreoretinal lymphoma (VRL) can commonly masquerade as chronic idiopathic uveitis due to its nonspecific clinical presentation. Thus, its early diagnosis is difficult. In this study, new logistic regression models were used to classify VRL and uveitis. Additionally, the diagnostic performance of interleukin (IL)-10, the IL-10/IL-6, and the Interleukin Score for IntraOcular Lymphoma Diagnosis (ISOLD) are evaluated.

methodsSixty-nine aqueous humors (AH) (46 VRL, 23 uveitis) and 65 vitreous humors (VH) (49 VRL, 16 uveitis) were collected from a single-center retrospective cohort. Logistic regression models were conducted based on IL-6 and IL-10. The cut-off values, area under the receiver operating characteristic curve (ROC) curve (AUC), sensitivity and specificity of IL-10, the IL-10/IL-6, the ISOLD, and the models were calculated from the ROC. Furthermore, Spearman's rank correlation analysis was performed to determine cytokine levels in VH and AH.

resultsWe redefined the cut-off values of IL-10, the IL-10/IL-6, the ISOLD, and the logistic regression models. In AH, the AUC values of IL-10, ISOLD, IL10/IL6, and the model were 0.91, 0.953, 0.952, and 0.967. In VH, they were 0.93, 0.95, 0.954, and 0.954, respectively. IL-6 (r = 0.7844) and IL-10 (r = 0.8506) in AH and VH showed a strong correlation.

conclusionsIL-6 and IL-10 levels were introduced into new logistic regression models. The diagnostic efficacy of the models improved compared to the indicators mentioned above among Chinese patients. Additionally, the models could predict the probability of VRL more accurately. A strong correlation of cytokine levels showed the great potential of AH as prioritized auxiliary diagnostic for VRL.

Indexed as

Eye NeoplasmsIntraocular LymphomaLymphoma, Non-HodgkinRetinal NeoplasmsUveitisCytokinesHumansInterleukin-10Interleukin-6InterleukinsLogistic ModelsRetrospective StudiesVitreous BodyCytokinesInterleukin-10Interleukin-6InterleukinsIL-10IL-6ISOLDlogistic regression modelsuveitisvitreoretinal lymphoma

Identifiers

PMID36098043
PMCPMC9550960
OpenAlexW4295514730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.