Evidence map›Paper›PMID 36097965›Full record

ArticleMolecular omics2022

Proteomic changes associated with racial background and sepsis survival outcomes.

Kathryn L Kapp, Albert B Arul, Kevin C Zhang, Liping Du, Sachin Yende, John A Kellum, Derek C Angus, Octavia M Peck-Palmer, Renã A S Robinson

Abstract read
In one paragraph

Article in Molecular omics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kathryn L KappDepartment of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA.ORCID 0000-0002-1468-8569
Albert B ArulDepartment of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA.
Kevin C ZhangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Liping DuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Sachin YendeThe Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
John A KellumDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Derek C AngusThe Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Octavia M Peck-PalmerThe Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Renã A S RobinsonDepartment of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA.ORCID 0000-0001-6307-8671
University of Pittsburgh · USVanderbilt University · USVanderbilt University Medical Center · US

Funding

Protocolized Care for Early Septic Shock (ProCESS)P50GM076659 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C · 2006 to 2012
$11.2M
Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Genetic And Inflammatory Markers Of SepsisR01GM061992 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C · 2001 to 2004
$6.0M
Predicting Risk of Pneumonia in the General PopulationK23GM083215 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YENDE, SACHIN · 2008 to 2012
$597k
NIGMS NIH HHS K23 GM083215NIGMS NIH HHS P50 GM076659NIGMS NIH HHS R01 GM061992NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

Intra-abdominal infection is a common cause of sepsis, and intra-abdominal sepsis leads to ∼156 000 U.S. deaths annually. African American/Black adults have higher incidence and mortality rates from sepsis compared to Non-Hispanic White adults. A limited number of studies have traced survival outcomes to molecular changes; however, these studies primarily only included Non-Hispanic White adults. Our goal is to better understand molecular changes that may contribute to differences in sepsis survival in African American/Black and Non-Hispanic White adults with primary intra-abdominal infection. We employed discovery-based plasma proteomics of patient samples from the Protocolized Care for Early Septic Shock (ProCESS) cohort (

Indexed as

Intraabdominal InfectionsProteomicsSepsisAdultBlack or African AmericanHumansWhite

Identifiers

PMID36097965
PMCPMC13626137
OpenAlexW4295512639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.