ArticleClinical and experimental reproductive medicine2022
Sperm DNA fragmentation negatively influences the cumulative live birth rate in the intracytoplasmic sperm injection cycles of couples with unexplained infertility.
Article in Clinical and experimental reproductive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Evidence-based guideline: unexplained infertility†.Human reproduction (Oxford, England) · 2023Guideline
- Enhancing intrauterine insemination success in advanced maternal age: Impact of consecutive ejaculate and optimised cycle parameters.JBRA assisted reproduction · 2026Article
- Expert-Annotated Optical Microscopy Images of Human Sperm for Detection and DNA Fragmentation Assessment.Scientific data · 2025Article
- The role of sperm DNA fragmentation in reproduction: a SWOT analysis.Journal of assisted reproduction and genetics · 2025Review
- Impact of Maternal Age on the Repairing Capacity of Oocytes on Paternal DNA Damage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- High sperm DNA fragmentation - finding a needle in the haystack: tips on selecting the best sperm for ICSI and ART.Asian journal of andrology · 2025Article
- Exploring the link between chromosomal polymorphisms and reproductive abnormalities.Reproductive health · 2024Article
- Changes in Sperm Parameters with Time in Men with Normal and Abnormal Baseline Semen Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Improved sperm DNA fragmentation levels in infertile men following very short abstinence of 3-4 hours.Translational andrology and urology · 2023Article
- Intra-individual changes in sperm DNA fragmentation levels over short and long time periods.Journal of assisted reproduction and genetics · 2023Article
- Polymorphic Rearrangements of Human Chromosome 9 and Male Infertility: New Evidence and Impact on Spermatogenesis.Biomolecules · 2023Article
- Migration-Gravity Sedimentation: An Effective Approach for Reducing Sperm DNA Fragmentation With Comparable Intracytoplasmic Sperm Injection Outcomes Compared to Density Gradient Centrifugation.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to determine the effect of sperm DNA fragmentation (SDF) on the cumulative live birth rate (CLBR) in intracytoplasmic sperm injection (ICSI) cycles in couples with unexplained infertility.
methodsWe conducted a prospective study of 145 couples who underwent ICSI cycles for unexplained infertility. Based on the SDF rate, patients were categorized into a low SDF group (SDF ≤30%, n=97) and a high SDF group (SDF >30%, n=48). SDF was assessed using the acridine orange test on density gradient centrifugation prepared samples. The CLBR was calculated as the first live birth event per woman per egg collection over 2 years.
resultsThe high SDF group (SDF >30%) showed a significantly lower CLBR (p<0.05) and a significantly higher miscarriage rate (p<0.05) than the low SDF group (SDF ≤30%). No significant difference was observed in the implantation and cumulative pregnancy rates between the two SDF groups. The total number of embryo transfers was stratified further into fresh and frozen embryo transfers. In the fresh embryo transfers, there were significant differences in the implantation rates, clinical pregnancy rates, and live birth rates (p<0.05) between the low SDF and high SDF groups. However, in the frozen embryo transfers, there were no significant differences in clinical outcomes between the two groups. In the multivariable logistic regression analysis, SDF was a predictor of CLBR (p<0.05) when adjusted for possible confounding factors.
conclusionHigh SDF was associated with a lower CLBR and a higher miscarriage rate in the ICSI cycles of couples with unexplained infertility.
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