ArticleBJPsych open2022
Antidepressant use and risk of adverse outcomes: population-based cohort study.
Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular mortality and depression: A systematic review and meta-analysis of the association with antidepressant treatment and co-morbidity.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- Antidepressant Use and Mortality Among Patients With Hepatocellular Carcinoma.JAMA network open · 2023Trial
- Safety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders.Molecules (Basel, Switzerland) · 2026Review
- Long-Term Antidepressant Use and Dementia Risk: A Propensity Score-Matched Study of Swiss Older Adults, with an Anticholinergic-Specific Analysis.Drugs - real world outcomes · 2026Article
- Article
- Article
- Reduced prevalence of periodontitis in antidepressant users: Findings from a large-scale US sample.Journal of periodontology · 2026Article
- External validation of the SMART2 model for recurrent cardiovascular risk: performance in socioeconomic, ethnic and psychiatric subgroups.Open heart · 2026Article
- Examining individual serotonin and norepinephrine reuptake inhibitors and fall-related hospitalizations in older adults.The mental health clinician · 2026Article
- Increasing Prevalence of Long-Term Antidepressant Use in Australia: A Retrospective Observational Study.Pharmacoepidemiology and drug safety · 2025Observational
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Article
- Patterns and Duration of Antidepressant Use in Australian Women: Findings From the Australian Longitudinal Study on Women's Health.Asia-Pacific journal of public health · 2025Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- Neurological adverse events associated with antidepressants: a comprehensive 22-year analysis of the FDA adverse event reporting system.Frontiers in pharmacology · 2025Article
- Extracellular vesicles from water kefir can interact with human neurons in vitro: a potential explanation for the role of probiotics consumption in mental health.AIMS neuroscience · 2025Article
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Potential deprescribing indications for antidepressants between 2012 and 2019: repeated cross-sectional analysis in two Scottish health boards.BMC medicine · 2024Article
- Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method.BMC medicine · 2024Article
- Pre-intensive care unit use of selective serotonin reuptake inhibitors and mortality in critically ill adults with mental disorders: analysis from the MIMIC-IV database.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAntidepressants are one of the most widely prescribed drugs in the global north. However, little is known about the health consequences of long-term treatment.
aimsThis study aimed to investigate the association between antidepressant use and adverse events.
methodThe study cohort consisted of UK Biobank participants whose data was linked to primary care records (
resultsSSRI treatment was associated with decreased risk of diabetes at 5 years (hazard ratio 0.64, 95% CI 0.49-0.83) and 10 years (hazard ratio 0.68, 95% CI 0.53-0.87), and hypertension at 10 years (hazard ratio 0.77, 95% CI 0.66-0.89). At 10-year follow-up, SSRI treatment was associated with increased risks of CV (hazard ratio 1.34, 95% CI 1.02-1.77), CVD mortality (hazard ratio 1.87, 95% CI 1.38-2.53) and all-cause mortality (hazard ratio 1.73, 95% CI 1.48-2.03), and 'other' class treatment was associated with increased risk of CHD (hazard ratio 1.99, 95% CI 1.31-3.01), CVD (hazard ratio 1.86, 95% CI 1.10-3.15) and all-cause mortality (hazard ratio 2.20, 95% CI 1.71-2.84).
conclusionsOur findings indicate an association between long-term antidepressant usage and elevated risks of CHD, CVD mortality and all-cause mortality. Further research is needed to assess whether the observed associations are causal, and elucidate the underlying mechanisms.
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Registered trials
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