Evidence map›Paper›PMID 36097560›Full record

ReviewThe Japanese dental science review2022

Silver diamine fluoride therapy for dental care.

Faith Miaomiao Zheng, Iliana Gehui Yan, Duangporn Duangthip, Sherry Shiqian Gao, Edward Chin Man Lo, Chun Hung Chu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Japanese dental science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Effects of Bleaching Protocols on the Esthetic Outcome and Surface Integrity of Enamel Treated With an Ammonia-Free Silver Fluoride Solution.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Article
  6. Article
  7. Article
  8. Review
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  10. Knowledge and attitudes regarding silver diamine fluoride among Brazilian dentists: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. TheBiomaterial investigations in dentistry · 2026
    Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Faith Miaomiao ZhengFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
Iliana Gehui YanFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
Duangporn DuangthipFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
Sherry Shiqian GaoFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
Edward Chin Man LoFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
Chun Hung ChuFaculty of Dentistry, The University of Hong Kong, 999077, Hong Kong, China.
University of Hong Kong · HKChinese University of Hong Kong · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver diamine fluoride (SDF) was developed in Japan in the 1960s. It is used to control early childhood caries, arrest root caries, prevent fissure caries and secondary caries, desensitise hypersensitive teeth, remineralise hypomineralised teeth, prevent dental erosion, detect carious tissue during excavation and manage infected root canals. SDF is commonly available as a 38% solution containing 255,000 ppm silver and 44,800 ppm fluoride ions. Silver is an antimicrobial and inhibits cariogenic biofilm. Fluoride promotes remineralisation and inhibits the demineralisation of teeth. SDF also inactivates proteolytic peptidases and inhibits dentine collagen degradation. It arrests caries without affecting dental pulp or causing dental fluorosis. Indirect pulp capping with SDF causes no or mild inflammatory pulpal response. However, direct application of SDF to dental pulp causes pulp necrosis. Furthermore, SDF stains carious lesions black. Patients must be well informed before SDF treatment. SDF therapy is simple, painless, non-invasive, inexpensive, and requires a simple armamentarium and minimal support. Both clinicians and patients generally accept it well. In 2021, the World Health Organization included SDF as an essential medicine that is effective and safe for patients. Moreover, it can be used for caries control during the COVID-19 pandemic because it is non-aerosol-generating and has a low risk of cross-infection.

Indexed as

CariesDentineHypersensitivityPreventionSilver diamine fluoride

Identifiers

PMID36097560
PMCPMC9463534
OpenAlexW4295066228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.