Evidence map›Paper›PMID 36097465›Full record

ArticleHeart rhythm O22022

Role of interatrial conduction in atrial fibrillation: Mechanistic insights from renewal theory-based fibrillatory dynamic analysis.

Jing Xian Quah, Evan Jenkins, Dhani Dharmaprani, Kathryn Tiver, Corey Smith, Teresa Hecker, Majo X Joseph, Joseph B Selvanayagam, Matthew Tung, Tony Stanton and 6 more

Open access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Role of interatrial connection ablation in re-entry dynamics: an in silico evaluation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Jing Xian QuahCollege of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia.
Evan JenkinsCollege of Science and Engineering, Flinders University of South Australia, Adelaide, Australia.
Dhani DharmapraniCollege of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia.
Kathryn TiverDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Corey SmithDepartment of Cardiology, Fiona Stanley Hospital, Perth, Australia.
Teresa HeckerDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Majo X JosephDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Joseph B SelvanayagamDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Matthew TungDepartment of Cardiovascular Medicine, Sunshine Coast University Hospital, Birtinya, Australia.
Tony StantonDepartment of Cardiovascular Medicine, Sunshine Coast University Hospital, Birtinya, Australia.
Waheed AhmadDepartment of Cardiovascular Medicine, Princess Alexandra Hospital, Brisbane, Australia.
Nik StoyanovDepartment of Cardiology, Fiona Stanley Hospital, Perth, Australia.
Anandaroop LahiriDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Fahd ChahadiDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Cameron SingletonDepartment of Cardiovascular Medicine, Flinders Medical Centre, Adelaide, Australia.
Anand GanesanCollege of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia.
Flinders Medical Centre · AUFlinders University · AUFiona Stanley Hospital · AUGriffith University · AUPrincess Alexandra Hospital · AUSunshine Coast University Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Interatrial conduction has been postulated to play an important role in atrial fibrillation (AF). The pathways involved in interatrial conduction during AF remain incompletely defined. Objective: We recently showed physiological assessment of fibrillatory dynamics could be performed using renewal theory, which determines rates of phase singularity formation (λ Method: RENEWAL-AF is a prospective multicenter observational study recruiting AF ablation patients (ACTRN 12619001172190). We studied unipolar electrograms obtained from 16 biatrial locations prior to ablation using a 16-electrode Advisor HD Grid catheter. Renewal rate constants λ Results: Forty-one AF patients (28.5% female) were recruited. A positive linear correlation was observed between λ Conclusion: Our findings support the role of interseptal statistically determined electrical disrelation in sustaining AF. Additionally, renewal theory identified preferential conduction through specific interatrial pathways during fibrillation. These findings may be of importance in identifying clinically significant targets for ablation in AF patients.

Indexed as

Atrial fibrillationBachmann’s bundleInteratrial conductionInteratrial septumRenewal theory

Identifiers

PMID36097465
PMCPMC9463713
OpenAlexW4280546711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.