ArticleHeart rhythm O22022
Pulsed-field ablation: Computational modeling of electric fields for lesion depth analysis.
Article in Heart rhythm O2, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Initial clinical experience with the balloon-in-basket pulsed field ablation system: acute results of the VOLT CE mark feasibility study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Trial
- The potato model: A root of all pulsed field ablation experimentation?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Three-Dimensional Left Atrial Geometry in Atrial Fibrillation: Imaging Biomarkers, Substrate Phenotyping, and Ablation Outcome Prediction.Diagnostics (Basel, Switzerland) · 2026Review
- The impact of operator experience on the recurrence rate for atrial fibrillation patients after radiofrequency ablation.Pakistan journal of medical sciences · 2026Article
- Evaluation of a Novel Multielectrode Surgical Pulsed Field Ablation Clamp: An Ex-Vivo Vegetal Study.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Single or multiple pulsed field applications: Intracardiac electrogram changes and implications for procedural end points.Heart rhythm O2 · 2026Article
- Hemolysis in Pulsed Field Ablation for Atrial Fibrillation: A Narrative Review.Reviews in cardiovascular medicine · 2026Review
- Atrial fibrillation: from pathogenesis to novel treatment options.Molecular biomedicine · 2025Review
- A randomized controlled trial of two pulsed field ablation systems for paroxysmal atrial fibrillation: the DUAL-PULSE trial rationale and design.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Pulsed Field Ablation-Related Hemolysis: Comparison Between Technologies.Circulation. Arrhythmia and electrophysiology · 2025Article
- Role of Computational Modelling in Enhancing Thermal Safety During Cardiac Ablation.Interdisciplinary cardiovascular and thoracic surgery · 2025Review
- Pulsed electric field ablation process-the effect of bifurcation stents on electric field and heat distribution.Scientific reports · 2025Article
- Biophysics and Clinical Effectiveness of Irreversible Electroporation for Catheter Ablation of Atrial Fibrillation.Journal of cardiovascular development and disease · 2025Review
- Effects of electric field and heat distribution due to trends in metal stent diameter in epicardial pulsed field ablation.Scientific reports · 2025Article
- Is a single lethal electric field threshold sufficient to characterize the lesion size in computational modeling of cardiac pulsed-field ablation?Heart rhythm O2 · 2025Article
- Feasibility study of intravascular pulsed electric field ablation for the treatment of cardiac arrhythmias.Frontiers in physiology · 2025Article
- Pulsed field ablation for ventricular arrhythmias with pentaspline catheter.Frontiers in cardiovascular medicine · 2025Article
- 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Journal of arrhythmia · 2024Article
- Comparison of efficiency of PFA catheter designs by computer modeling.Journal of cardiovascular electrophysiology · 2024Article
- In Vitro Assay Development to Study Pulse Field Ablation Outcome Using Solanum Tuberosum.International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulsed-field ablation (PFA) is an emerging and promising nonthermal technology for cardiac ablation. The effective applied voltage to achieve adequate irreversible myocardial injury is not well studied. The pulsed-field strength remains independent of tissue contact; therefore, PFA is assumed to be an ablation technology, not mandating the need for tissue contact. Objective: Determine the effect of applied voltage and distance to surface on depth of myocardial injury using PFA. Methods: A computational model was developed and validated based on extracted data from in vivo studies to examine the effect of different applied voltages and the impact of distance between the catheter and endocardial surface on the depth of irreversible myocardial injury using PFA. Results: The depth of lesions created by PFA are dose-dependent, and there is a direct correlation between applied PFA voltages and depth of irreversible myocardial injury. The minimum applied voltage of PFA required to create a lesion deeper than 1 mm is 300 volts. The catheter-tissue contact plays a pivotal role in determining lesion depth. With optimal catheter contact in the absence of trabeculation, the minimal applied energy required to achieve a 3-mm-deep lesion is 700 volts. A minor increase in the catheter-tissue distance of 1-2 mm doubles the minimum required applied voltage, increasing it to 1500 volts. Conclusion: PFA is an important new technology that is proposed to be more efficacious and safer than currently used thermal ablation. Here we demonstrate the impact of dose dependence and the need for maintaining tissue contact during ablation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.