ArticleNature medicine2022
Genetic risk factors have a substantial impact on healthy life years.
Article in Nature medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Harnessing data science to control non-communicable diseases in Africa: a systematic review and gap analysis.Communications medicine · 2026Article
- Do Genetic Variants Directly Shape Population-Level Schizophrenia Burden? A Global Genomic Analysis.Biological psychiatry global open science · 2026Article
- Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status.Communications medicine · 2026Article
- The rs3024839 and rs2227483 polymorphisms with immune pathomechanism offers a starting point for diagnosis and susceptibility testing of myocardial infarction.Scientific reports · 2026Article
- Article
- Exome-Wide Analysis Identifies a RareKidney international reports · 2026Article
- Modifiable influencing factors and their joint effects on early- and late-onset coronary heart disease.Nature communications · 2025Article
- Associations of sleep, lifestyle, and physiological markers with healthspan termination: a prospective cohort analysis.Sleep & breathing = Schlaf & Atmung · 2025Article
- Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).Environmental and molecular mutagenesis · 2025Review
- ThebioRxiv : the preprint server for biology · 2025Article
- Exposure accumulation drives age-dependent disease architectures and polygenic risk scores.medRxiv : the preprint server for health sciences · 2025Article
- The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases.medRxiv : the preprint server for health sciences · 2025Article
- Impact of genetic risk and lifestyles on cardiovascular disease-free and total life expectancy: a cohort study.Genome medicine · 2025Article
- Association between Prenatal Particulate Matter Exposure and Neuropsychiatric Disorders Development.Biomolecules & therapeutics · 2025Review
- Polygenic Risk Scores in Human Disease.Clinical chemistry · 2025Review
- NovelPharmacogenomics and personalized medicine · 2025Article
- Can AI developers avoid bias in public health applications?Frontiers in public health · 2025Article
- Sex Based Comparison of Health Self-Perception, Sleep, Anxiety, and Body Composition Among University Students.International journal of public health · 2025Article
- Demographic diversity in platelet function and response to antiplatelet therapy.Trends in pharmacological sciences · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; 'lost healthy life years'). We use genetic information from 735,748 individuals and consider 80 diseases. Rare variants had the highest effect on DALYs at the individual level. Among common variants, rs3798220 (LPA) had the strongest individual-level effect, with 1.18 DALYs from carrying 1 versus 0 copies. Being in the top 10% versus the bottom 90% of a polygenic score for multisite chronic pain had an effect of 3.63 DALYs. Some common variants had a population-level effect comparable to modifiable risk factors such as high sodium intake and low physical activity. Attributable DALYs vary between males and females for some genetic exposures. Genetic risk factors can explain a sizable number of healthy life years lost both at the individual and population level.
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