ArticleNature communications2022
Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 272 citations in OpenAlex.
- Robust and durable zwitterionic hydrogel coating with catechol-CuBioactive materials · 2026Article
- Photoinitiated Regulated Silver-Releasing Zwitterionic Hydrogel Coating for Antibacterial, Antifouling, and Thrombus-Resistant PVC Catheters.ACS omega · 2026Article
- A Pure Zwitterionic PSBMA Coating With Ultra-Low Friction, Anti-Adhesion and High Stability for Blood-Contacting Catheters.Macromolecular bioscience · 2026Article
- Hydrogel-Based Delivery of Ion Channel Modulators for Cancer Therapy: Current Advances and Future Perspectives.Gels (Basel, Switzerland) · 2026Review
- Spatiotemporal liposome-zwitterionic nano-hydrogel orchestrates immunomodulation and neurogenesis in spinal cord injury repair.Materials today. Bio · 2026Article
- Four-dimensional reconfigurable vascular tunneling machine of spatially programmed liquid crystal elastomers.Nature communications · 2026Article
- An embolism-free nonfouling hydrogel coating with high toughness and lubricity for intravascular medical devices via chain-entanglement mediated topological gelation.Bioactive materials · 2026Article
- Radical-Mediated, Substrate-Independent Fabrication of Hybrid Solid-Hydrogel Materials With Tunable Crosslinking: An Initiator- and Crosslinker-Free Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomass-Based Antifouling Coatings: Mechanisms, Materials, Applications, and Emerging Sustainable Strategies.Nano-micro letters · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- High drug-loaded supramolecular microgels enabled by controlled in-droplet self-assembly for adaptive treatment of inflammatory arthritis.Bioactive materials · 2026Article
- Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance.Nature communications · 2026Article
- Antithrombotic Polymers: A Narrative Review on Current and Future Strategies for Their Design, Synthesis, and Application.International journal of molecular sciences · 2026Review
- Temperature-Induced Morphological Transitions for On-Demand Detachment in Worm-Based Polymer Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- Advances in Surface Biofunctionalization and Intelligent Monitoring of Vascular Scaffolds.Research (Washington, D.C.) · 2026Review
- Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system.Scientific reports · 2025Article
- Robust zwitterionic hydrogels enabled by consolidated supramolecular networks and spatially hierarchical structures.Nature communications · 2025Article
- Robust Antifogging and Antifouling Coating Tailored with Zwitterionic Nanocellulose for Multi-Functional Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bonding of Hydrogel to Biometal Surfaces: Principles, Methods and Applications.Exploration (Beijing, China) · 2025Review
- Direct laser writing of electronically conductive microstructures within soft hydrogel substrates.Materials today. Bio · 2025Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zwitterionic hydrogels exhibit eminent nonfouling and hemocompatibility. Several key challenges hinder their application as coating materials for blood-contacting biomedical devices, including weak mechanical strength and low adhesion to the substrate. Here, we report a poly(carboxybetaine) microgel reinforced poly(sulfobetaine) (pCBM/pSB) pure zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties. The pCBM/pSB hydrogel coating was bonded to the PVC substrate via the entanglement network between the pSB and PVC chain. Moreover, the pCBM/pSB hydrogel coating can maintain favorable stability even after 21 d PBS shearing, 0.5 h strong water flushing, 1000 underwater bends, and 100 sandpaper abrasions. Notably, the pCBM/pSB hydrogel coated PVC tubing can not only mitigate the foreign body response but also prevent thrombus formation ex vivo in rats and rabbits blood circulation without anticoagulants. This work provides new insights to guide the design of pure zwitterionic hydrogel coatings for biomedical devices.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.