ArticleBMC ophthalmology2022
Incidence and risk factors for retinopathy of prematurity in premature, extremely low birth weight and extremely low gestational age infants.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Incidence and risk factors for retinopathy of prematurity: A hospital-based study in Iran.Eye (London, England) · 2026Article
- [Predictive factors for retinopathy of prematurity in a hospital from Bajío].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Article
- Network Pharmacology and Experimental Validation Elucidate the Anti-Angiogenic Mechanism of Silibinin.Chemistry & biodiversity · 2026Article
- Which Bacterial Agent Is More Influential in the Development of Retinopathy of Prematurity: Gram-Positive or Gram-Negative?Children (Basel, Switzerland) · 2026Article
- Retinopathy of Prematurity: Historical Evolution of Clinical Management and Medico-Legal Evaluation in Japan.Healthcare (Basel, Switzerland) · 2026Review
- Evaluation of regression, reactivation, retreatment and retinal detachment after injections of three different anti-VEGF drugs for retinopathy of prematurity.Scientific reports · 2026Article
- Machine learning-based individualized prediction: risk assessment of retinopathy in preterm infants at high altitude.BMC ophthalmology · 2026Article
- Use of Aflibercept to Treat Retinopathy of Prematurity in Children with Extremely Low Birth Weight.Journal of clinical medicine · 2026Article
- Swept-source optical coherence tomography analysis of retinal and choroidal structures in school-aged children after laser photocoagulation for type 1 retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Factors associated with loss to follow-up in retinopathy of prematurity screening referrals at a South African tertiary hospital: A retrospective cohort study.Journal of the colleges of medicine of South Africa · 2026Article
- Analysis of the incidence and risk factors associated with retinopathy of prematurity in patients complicated by bronchopulmonary dysplasia.Annals of medicine · 2025Article
- Correlation between histologic chorioamnionitis and severe retinopathy of prematurity.Pediatric research · 2025Article
- Prognostic nutritional index in retinopathy of prematurity: a potential indicator of disease severity?International ophthalmology · 2025Article
- The use of neural networks to determine factors affecting the severity and extent of retinopathy in preterm infants.International journal of retina and vitreous · 2025Article
- Phlebotomy-induced anemia reduces oxygen-induced retinopathy severity and dampens retinal developmental transcriptomic pathways in rats.Pediatric research · 2025Article
- Red blood cell parameters as biomarkers of retinopathy of prematurity in preterm infants born before 30 weeks of gestation.Scientific reports · 2025Article
- Identifying neonatal hyperglycemia thresholds in preterm infants based on retinopathy of prematurity outcomes: proof-of-concept study.Frontiers in pediatrics · 2025Article
- The relationship between inflammatory markers and retinopathy of prematurity in extremely premature infants.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Clinical and Growth Correlates of Retinopathy of Prematurity in Preterm Infants with Surgical Necrotizing Enterocolitis and Intestinal Perforation.American journal of perinatology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the study was to determine the incidence and risk factors of retinopathy of prematurity (ROP) in premature, extremely low birth weight (BW, ELBW) and extremely low gestational age (GA, ELGA) infants.
methodsThe medical records of preterm infants who were screened for ROP between January 2012 and December 2020 were retrospectively reviewed. Only one eye of each infant with higher grade ROP was included in the study. BW; GA; medical characteristics; the presence, severity, and need for treatment of ROP were recorded. Infants were divided into groups according to BW (≤1000 g, 1001-1750 g, > 1750 g) and GA (≤25w, 26-28w, 29-31w, 32-34w, ≥35w) and data were analyzed.
resultsData of 2186 infants were evaluated. The overall incidences of any stage ROP and ROP requiring treatment were 43.5 and 8.0%, respectively. These rates were 81.1 and 23.9% in ELBW (≤1000 g) infants and were 92.9 and 64.3% in ELGA (≤25w) infants, respectively. The rates of ROP, the median duration of oxygen therapy and systemic diseases increased significantly as BW and GA decreased. The median duration of oxygen therapy and the rates of sepsis, pulmonary dysplasia (BPD), and intraventricular hemorrhage (IVH) were statistically higher in infants with ROP compared to those without ROP (p < 0.001). Multivariate regression analysis demonstrated that low BW and GA; prolonged duration of oxygen therapy; presence of PDA and necrotizing enterocolitis (NEC) were important risk factors for ROP.
conclusionsELBW and ELGA infants develop higher rates of ROP and severe ROP. Prolonged duration of oxygen therapy, the presence of concomitant neonatal sepsis, BPD, IVH, PDA, and NEC further increases the risk of ROP.
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