ArticleRespiratory research2022
Characteristics of different asthma phenotypes associated with cough: a prospective, multicenter survey in China.
Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Extreme weather and asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Diagnosis and Treatment of Refractory Chronic Cough: An American Broncho-Esophagological Association Expert Consensus Statement.The Laryngoscope · 2026Article
- Cynaroside reduces neutrophil extracellular trap formation and disease severity in a mouse model of asthma by inhibiting the COX-2/TNF-alpha/NF-kB axis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Characteristics and management of asthma from the China Asthma Data Registry Project.ERJ open research · 2026Article
- Treatment response trajectories for speech pathology intervention in chronic cough.ERJ open research · 2026Article
- Predictors of cough resolution following endoscopic minimally invasive treatment in patients with GERD and chronic cough: a retrospective study.Frontiers in medicine · 2026Article
- Bronchial asthma: what is different in patients with and without chronic cough?Respiratory research & clinical practice · 2026Article
- Pulmonary function and risk factors in pediatric chest tightness variant asthma: a case-control study.Frontiers in pediatrics · 2026Article
- Associations of mucus plugging, small airway dysfunction, and airway wall thickening in cough-variant asthma versus asthma.European journal of medical research · 2025Article
- Identification of two distinct molecular endotypes in cough-variant asthma based on sputum transcriptomics and clinical pathophysiological features.ERJ open research · 2025Article
- The short-term effects of different cold spell definitions on asthma outpatient visits in Lanzhou, China.BMC pulmonary medicine · 2025Article
- Cough-Variant Asthma: A Review of Clinical Characteristics, Diagnosis, and Pathophysiology.The journal of allergy and clinical immunology. In practice · 2025Review
- Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity.Journal of asthma and allergy · 2025Article
- The role of Xuanfei Zhisou mixture plus fluticasone propionate suspension in the treatment of variant cough in children and its effect on serum amyloid A and c-reactive protein.Frontiers in medicine · 2025Article
- The Value of Body Plethysmography (sGaw) in the Assessment of Airway Hyperreactivity in Cough Variant Asthma.Journal of clinical medicine · 2024Article
- Bibliometric Analysis of Cough Variant Asthma from 1993 to 2022.Journal of asthma and allergy · 2024Article
- Patient response to the management during the acute presentation of cough variant Asthma: Retrospective cohort study.Saudi journal of biological sciences · 2023Article
- An Early Sign? Low Birth Weight and Childhood Respiratory Infections as Predictors of Chronic Cough in Adult Asthma.Open respiratory archivesArticle
- Phenotypes and endotypes of cough in asthma.Therapeutic advances in respiratory diseaseReview
Corrections and comments
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Authors and funding
27 authors at 20 institutions in 2 countries.
Funding
Abstract
backgroundAsthma is a heterogeneous disease with variable symptoms, which presents with cough either as the sole or predominant symptom with or without wheezing. We compared the clinical and pathophysiological characteristics of cough predominant asthma (CPA), cough variant asthma (CVA) and classic asthma (CA) in order to determine any differential phenotypic traits.
methodsIn 20 clinics across China, a total of 2088 patients were finally recruited, including 327 CVA, 1041 CPA and 720 CA patients. We recorded cough and wheezing visual analogue scale, Leicester cough questionnaire (LCQ) and asthma control test scores. Fractional exhaled nitric oxide (FeNO), induced sputum cell counts, and capsaicin cough challenge were also measured and compared.
resultsCPA patients more frequently presented with cough as the initial symptom, and laryngeal symptoms (p < 0.001), had less symptoms related with rhinitis/sinusitis and gastroesophageal reflux (p < 0.05) than CA patients. Comorbidities including rhinitis and gastroesophageal reflux were similar, while the proportion of COPD and bronchiectasis was higher in CA patients. There were no differences in FeNO levels, sputum eosinophil and neutrophil counts, FEV1 (%pred) decreased from CVA to CPA to CA patients (p < 0.001). Cough sensitivity was higher in CVA and CPA compared to CA (p < 0.001), and was positively correlated with LCQ scores.
conclusionsCVA, CPA and CA can be distinguished by the presence of laryngeal symptoms, cough sensitivity and airflow obstruction. Asthma-associated chronic cough was not associated with airway inflammation or comorbidities in our cohort. Trial registration The Chinese Clinical Trial Registration Center, ChiCTR-POC-17011646, 13 June 2017.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.