Evidence map›Paper›PMID 36096645›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.

Simon Bélanger, Sonya Haupt, Brian L Freeman, Adam J Getzler, Huitian Diao, Matthew E Pipkin, Shane Crotty

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. In Situ Characterization of Human Follicular Helper CD4 T Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Simon BélangerDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA.
Sonya HauptDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-8371-3713
Brian L FreemanDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-9496-9001
Adam J GetzlerDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL.ORCID 0000-0001-8091-3851
Huitian DiaoDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL.
Matthew E PipkinDepartment of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL.ORCID 0000-0002-9688-0190
Shane CrottyDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA; shane@lji.org.ORCID 0000-0002-6484-6262
Scripps Research Institute · USLa Jolla Institute for Immunology · US

Funding

Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and functionP01AI145815 · NIAID · UNIVERSITY OF FLORIDA · PI PIPKIN, MATTHEW EUGENE · 2020 to 2024
$11.0M
TF regulation of CD8 and CD4 T cell memory in both systemic and dermal infectionU19AI109976 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN · 2014 to 2018
$10.5M
Tfh and SAP and T cell help to B cellsR01AI072543 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2008 to 2018
$4.6M
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NIAID NIH HHS P01 AI145815NIAID NIH HHS R01 AI072543NIAID NIH HHS U19 AI109976
6 · The paper itself

Abstract

T follicular helper (T

Indexed as

Germinal CenterT-Lymphocytes, Helper-InducerAnimalsCell DifferentiationLymphocyte ActivationMiceRNA, Small InterferingT Follicular Helper CellsTranscription FactorsRNA, Small InterferingTranscription Factors

Identifiers

PMID36096645
PMCPMC11139054
OpenAlexW4295509266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.