Evidence map›Paper›PMID 36096354›Full record

Trial reportOphthalmology. Glaucoma

Eye Dynamics and Engineering Network Consortium: Baseline Characteristics of a Randomized Trial in Healthy Adults.

David M Reed, Carol B Toris, Jesse Gilbert, Matthew Trese, Tyler J Kristoff, Shan Fan, Donna Neely, Simone Ferguson, Arash Kazemi, Jay W McLaren and 4 more

Open access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Understanding Individual Intraocular Pressure Response to Treatment with Latanoprost and Timolol.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2025
    Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

David M ReedDepartment of Ophthalmology and Visual Sciences, Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio.
Carol B TorisDepartment of Ophthalmology and Visual Sciences, Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio; Department of Ophthalmology and Visual Sciences, Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.
Jesse GilbertDepartment of Ophthalmology and Visual Sciences, Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio.
Matthew TreseKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; Beaumont Eye Institute, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan.
Tyler J KristoffKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; J. Willis Hurst Internal Medicine Residency, Emory University School of Medicine, Atlanta, Georgia.
Shan FanDepartment of Ophthalmology and Visual Sciences, Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.
Donna NeelyDepartment of Ophthalmology and Visual Sciences, Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.
Simone FergusonHoward University Hospital, Washington, District of Columbia.
Arash KazemiDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Jay W McLarenDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Vikas GulatiDepartment of Ophthalmology and Visual Sciences, Stanley Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.
David C MuschKellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Arthur J SitDepartment of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Sayoko E MoroiDepartment of Ophthalmology and Visual Sciences, Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio; Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. Electronic address: sayoko.moroi@osumc.edu.
Mayo Clinic · USThe Ohio State University Wexner Medical Center · USUniversity of Nebraska Medical Center · USUniversity of Michigan · USEmory University · USHoward University Hospital · USOakland University · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 ResearchU41HG007050 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2013 to 2022
$21.2M
VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
The Ohio State University Vision Sciences Research Core Program (OSU-VSRCP)P30EY032857 · NEI · OHIO STATE UNIVERSITY · PI Nathan Doble · 2022 to 2026
$3.6M
Aqueous Humor Dynamic Components that Determine Intraocular Pressure VarianceR01EY022124 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOROI, SAYOKO E · 2012 to 2022
$3.6M
NCATS NIH HHS UL1 TR000433NEI NIH HHS P30 EY007003NEI NIH HHS P30 EY032857NEI NIH HHS R01 EY022124NHGRI NIH HHS U41 HG007050
6 · The paper itself

Abstract

purposeTo improve understanding of intraocular pressure (IOP) and its variance, this project identifies systemic and ocular characteristics of healthy eyes of adult volunteers including IOP variation, ocular biometrics, and aqueous humor dynamics (AHDs). These data serve as baseline controls for further studies from the Eye Dynamics and Engineering Network (EDEN) Consortium.

designMulticenter open-label clinical trial in healthy adults randomized to 1 week treatment with 2 approved glaucoma drugs in a crossover design.

participantsAmong 135 healthy participants, 122 participants (aged 55.2 ± 8.8 years; 92 females, 30 males) completed the protocol.

methodsParticipants from the University of Michigan, Mayo Clinic, and University of Nebraska Medical Center underwent measurements of ocular biometrics, AHD, and IOP using 4 tonometers. Intraocular pressure data during 3 study visits without glaucoma medications were used in the analysis. The PhenX Toolkit survey acquired standardized data on medical history, surgical history, medications, smoking and alcohol exposures, and physical measures.

main outcome measuresThe variability of IOP measurements within eyes was assessed as visit-to-visit IOP variation, within-visit IOP variation, and within-visit positional IOP variation. The concordance (or correlation) between eyes was also assessed.

resultsAverage positional change of > 4.7 mmHg was detected with a range of 0.5-11.0 mmHg. Pearson correlation of IOP between eyes within a visit was 0.87 (95% confidence interval [CI], 0.82-0.91) for Goldmann applanation tonometry, 0.91 (95% CI, 0.88-0.94) for Icare rebound tonometry, and 0.91 (95% CI, 0.88-0.94) for pneumatonometry. There was a 4% to 12% asymmetric fluctuation of 3 mmHg or more between eyes between visits using rebound tonometry, 9% with Goldmann applanation tonometry, and 3% to 4% by pneumotonometry. The coefficient of variation between visits for the same eye ranged from 11.2% to 12.9% for pneumatonometry, from 13.6% to 17.4% for rebound tonometry, and 15.8% to 16.2% for Goldmann applanation tonometry.

conclusionsThe current study from the EDEN Consortium describes measurement methods and data analyses with emphasis on IOP variability. Future papers will focus on changes in ocular biometrics and AHD with timolol or latanoprost treatment. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Indexed as

GlaucomaAdultFemaleHumansIntraocular PressureMaleTonometry, OcularAqueous humor dynamics, Glaucoma, Intraocular pressure, IOP

Identifiers

PMID36096354
PMCPMC9998773
OpenAlexW4295297565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.