ArticleProceedings of the National Academy of Sciences of the United States of America2022
Implanted synthetic cells trigger tissue angiogenesis through de novo production of recombinant growth factors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Phosphoserine as an Alternative Energy Source forACS synthetic biology · 2026Article
- Bottom-Up Synthetic Biology for Artificial Cell Design: From Scaffold Materials to Functional Integration.Journal of microbiology and biotechnology · 2026Review
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Bioprinting in Tissue Repair and Its ENT Applications.Polymers · 2026Review
- Engineering synthetic cells with intramembrane domains possessing distinct bilayer asymmetries.Nature communications · 2026Article
- A microgel-stabilized, light-controlled artificial energy supply module for efficient biosynthesis.Regenerative biomaterials · 2026Article
- Combining Nanoscale Curvature and Polymer Osmotic Pressure for Efficient Giant Vesicle Assembly Under Physiological Conditions.Small methods · 2025Article
- Repurposing magnetic hyperthermia therapy to control biosynthesis in synthetic cells.Nature chemistry · 2025Article
- Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells.Nature chemistry · 2025Article
- Strategies and applications of synthetic cell communication.Nature chemical biology · 2025Review
- Thermally Driven Dynamic Behaviors in Polymeric Vesicles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.Science advances · 2025Article
- High-Resolution Patterned Delivery of Chemical Signals From 3D-Printed Picoliter Droplet Networks.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Spatiotemporal Control Over Protein Release from Artificial Cells via a Light-Activatable Protease.Advanced biology · 2025Article
- Light-Triggered Protease-Mediated Release of Actin-Bound Cargo from Synthetic Cells.Advanced biology · 2025Article
- Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications.Advanced biology · 2025Article
- Light-triggered protease-mediated release of actin-bound cargo from synthetic cells.bioRxiv : the preprint server for biology · 2024Article
- Vascularized 3D Human Skin Models in the Forefront of Dermatological Research.Advanced healthcare materials · 2024Review
- Artificial cells for in vivo biomedical applications through red blood cell biomimicry.Nature communications · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progress in bottom-up synthetic biology has stimulated the development of synthetic cells (SCs), autonomous protein-manufacturing particles, as dynamic biomimetics for replacing diseased natural cells and addressing medical needs. Here, we report that SCs genetically encoded to produce proangiogenic factors triggered the physiological process of neovascularization in mice. The SCs were constructed of giant lipid vesicles and were optimized to facilitate enhanced protein production. When introduced with the appropriate genetic code, the SCs synthesized a recombinant human basic fibroblast growth factor (bFGF), reaching expression levels of up to 9⋅10
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Registered trials
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