Evidence map›Paper›PMID 36095195›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2022

Daytime eating prevents mood vulnerability in night work.

Jingyi Qian, Nina Vujovic, Hoa Nguyen, Nishath Rahman, Su Wei Heng, Stephen Amira, Frank A J L Scheer, Sarah L Chellappa

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07761611 (Evaluation of Fatigue and Mitigations During Long-haul Operations), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07761611 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Fatigue and Mitigations During Long-haul Operations

TypeinterventionalSponsorNational Aeronautics and Space Administration (NASA)Ran2026 to 2029Enrolled118ConditionsAlertness, Fatigue, Mood, and Performance, Calorie Restriction and Light InterventionArmsCaloric restriction, Light exposure
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  17. The sleep-circadian interface: A window into mental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingyi QianMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.ORCID 0000-0002-8793-9330
Nina VujovicMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.
Hoa NguyenMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.
Nishath RahmanMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.
Su Wei HengMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.
Stephen AmiraDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-9523-6486
Frank A J L ScheerMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.ORCID 0000-0002-2014-7582
Sarah L ChellappaMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115.ORCID 0000-0002-6190-464X

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2021 to 2025
$3.9M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
Meal Time Effects on Metabolic Health.R01DK099512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.8M
Development of countermeasures against adverse metabolic effects of shift workR01HL118601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.6M
Timing of Physical Activity on Cardiometabolic Health OutcomesK99HL148500 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI QIAN, JINGYI · 2020 to 2021
$269k
NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR002541NHLBI NIH HHS K99 HL148500NHLBI NIH HHS R01 HL118601NHLBI NIH HHS R01 HL140574NHLBI NIH HHS R01 HL153969NIDDK NIH HHS R01 DK099512NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072
6 · The paper itself

Abstract

Shift workers have a 25 to 40% higher risk of depression and anxiety partly due to a misalignment between the central circadian clock and daily environmental/behavioral cycles that may negatively affect mood and emotional well-being. Hence, evidence-based circadian interventions are required to prevent mood vulnerability in shift work settings. We used a stringently controlled 14-d circadian paradigm to assess mood vulnerability during simulated night work with either daytime and nighttime or daytime-only eating as compared with simulated day work (baseline). Simulated night work with daytime and nighttime eating increased depression-like mood levels by 26.2% (

Indexed as

AnxietyCircadian ClocksDepressive DisorderMealsShift Work ScheduleWork Schedule ToleranceAdultCircadian RhythmFemaleHumansMaleYoung Adultcircadian disruptionmental healthmood vulnerabilityshift worksleep

Identifiers

PMID36095195
PMCPMC9499546

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.