Evidence map›Paper›PMID 36095184›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Electric fields control water-gated proton transfer in cytochrome

Patricia Saura, Daniel Riepl, Daniel M Frey, Mårten Wikström, Ville R I Kaila

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Quinones operate as proton-collecting antennas in energy-transducing membranes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. TheProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Proton-Coupled Electron Transfer in Cytochrome c Oxidase: Heme a Controls the Protonation Dynamics of E286.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Structural and functional mechanisms of cytochrome c oxidase.Journal of inorganic biochemistry · 2025
    Review
  13. Article
  14. Mechanism of proton release during water oxidation in Photosystem II.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patricia SauraDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0003-2575-9913
Daniel RieplDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0002-5641-3037
Daniel M FreyDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0002-1841-9008
Mårten WikströmInstitute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-7527-4415
Ville R I KailaDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm 10691, Sweden.ORCID 0000-0003-4464-6324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic life is powered by membrane-bound enzymes that catalyze the transfer of electrons to oxygen and protons across a biological membrane. Cytochrome

Indexed as

Electron Transport Complex IVProtonsAerobiosisElectron TransportOxygenWaterElectron Transport Complex IVOxygenProtonsWaterbioenergeticsheme-copper oxidasesmolecular simulationsPCETQM/MM

Identifiers

PMID36095184
PMCPMC9499568

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.