Evidence map›Paper›PMID 36095143›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Obesity Is Associated with Attenuated Tissue Immunity in COVID-19.

Shuang A Guo, Georgina S Bowyer, John R Ferdinand, Mailis Maes, Zewen K Tuong, Eleanor Gillman, Mingfeng Liao, Rik G H Lindeboom, Masahiro Yoshida, Kaylee Worlock and 16 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Characteristics of Human Donor Lungs Used for Research.American journal of respiratory cell and molecular biology · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Obesity and COVID-19 Disease: To Inflame or Not.American journal of respiratory and critical care medicine · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 6 countries.

Shuang A GuoMolecular Immunity Unit.ORCID 0000-0002-1712-9180
Georgina S BowyerMolecular Immunity Unit.ORCID 0000-0002-2058-4045
John R FerdinandMolecular Immunity Unit.ORCID 0000-0003-0936-0128
Mailis MaesCambridge Institute for Therapeutic Immunology and Infectious Disease.ORCID 0000-0002-0266-6557
Zewen K TuongMolecular Immunity Unit.ORCID 0000-0002-6735-6808
Eleanor GillmanMolecular Immunity Unit.ORCID 0000-0002-4221-7270
Mingfeng LiaoInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.
Rik G H LindeboomCellular Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-3660-504X
Masahiro YoshidaUCL Respiratory, Division of Medicine, University College London, London, United Kingdom.ORCID 0000-0002-3521-5322
Kaylee WorlockUCL Respiratory, Division of Medicine, University College London, London, United Kingdom.ORCID 0000-0002-5656-7634
Hudaa GopeeBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0001-8507-5682
Emily StephensonBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0002-4244-4019
Catherine A GaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0001-5576-3943
Paul A LyonsCambridge Institute for Therapeutic Immunology and Infectious Disease.ORCID 0000-0001-7035-8997
Kenneth G C SmithCambridge Institute for Therapeutic Immunology and Infectious Disease.ORCID 0000-0003-3829-4326
Muzlifah HaniffaCellular Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-3927-2084
Kerstin B MeyerCellular Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0001-5906-1498
Marko Z NikolićUCL Respiratory, Division of Medicine, University College London, London, United Kingdom.ORCID 0000-0001-6304-6848
Zheng ZhangInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China.ORCID 0000-0002-3544-1389
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-8527-4195
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0003-2879-3789
Gordon DouganCambridge Institute for Therapeutic Immunology and Infectious Disease.ORCID 0000-0003-0022-965X
Vilas NavapurkarJohn V. Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.ORCID 0000-0002-3610-3568
Sarah A TeichmannCellular Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-6294-6366
Andrew Conway MorrisDivision of Anaesthesia, Department of Medicine.ORCID 0000-0002-3211-3216
Menna R ClatworthyMolecular Immunity Unit.ORCID 0000-0002-3340-9828
Infectious Disease Research Institute · USWellcome Sanger Institute · GBNorthwestern University · USUniversity College London · GBNewcastle University · GBShenzhen Third People’s Hospital · CNCambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Lung transplant injury drives chronic lung allograft dysfunction via recruitment ofmonocyte-derived alveolar macrophagesR01HL153312 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISHARIN, ALEXANDER · 2020 to 2023
$2.9M
Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19R01HL158139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT, MISHARIN, ALEXANDER · 2022 to 2025
$2.9M
Medical Research Council MR/5005579/1Medical Research Council MR/R015635/1Medical Research Council MR/S005579/1Medical Research Council MR/V006118/1Medical Research Council MR/W00111X/1NHLBI NIH HHS R01 HL153312NHLBI NIH HHS R01 HL158139NIA NIH HHS P01 AG049665Wellcome TrustWellcome Trust WT206194Wellcome Trust WT211276/Z/18/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Interferon Type IPediatric ObesityAdultChildHumansLeukocytes, MononuclearLungSARS-CoV-2Interferon Type Ibronchoalveolar lavageCOVID-19obesitysingle-cell RNA sequencingtype-I interferon

Identifiers

PMID36095143
PMCPMC10870921
OpenAlexW4295462229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.