Evidence map›Paper›PMID 36094853›Full record

ArticleArthritis care & research2023

Racial Differences in Multimorbidity and Comorbidities in Rheumatoid Arthritis.

Vanessa L Kronzer, Hayley J Dykhoff, Maria A Stevens, Elena Myasoedova, John M Davis, Cynthia S Crowson

Abstract read
In one paragraph

Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
  2. Article
  3. Health Disparities in Rheumatology in the United States.Open access rheumatology : research and reviews · 2025
    Review
  4. Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention.Chinese journal of integrative medicine · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vanessa L KronzerMayo Clinic, Rochester, Minnesota.ORCID 0000-0002-7489-3134
Hayley J DykhoffMayo Clinic, Rochester, Minnesota.
Maria A StevensMayo Clinic, Rochester, Minnesota, OptumLabs, Eden Prairie, Minnesota, and University of North Carolina at Chapel Hill.
Elena MyasoedovaMayo Clinic, Rochester, Minnesota.ORCID 0000-0003-2006-1436
John M DavisMayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9710-8143
Cynthia S CrowsonMayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5847-7475

Funding

HEART DISEASE IN RHEUMATOID ARTHRITISR01AR046849 · NIAMS · MAYO CLINIC ROCHESTER · PI CROWSON, CYNTHIA S · 2000 to 2022
$11.3M
Role of Systemic Inflammation in Cognitive Decline: Rheumatoid Arthritis as a PrototypeR01AG068192 · NIA · MAYO CLINIC ROCHESTER · PI Elena Myasoedova · 2020 to 2026
$4.4M
Temporal associations between systemic inflammation, cardiovascular risk profile and development of Alzheimer’s disease and related dementias in patients with rheumatoid arthritisK24AG078179 · NIA · MAYO CLINIC ROCHESTER · PI Elena Myasoedova · 2022 to 2026
$951k
NIAMS NIH HHS R01 AR046849NIA NIH HHS K24 AG078179NIA NIH HHS R01 AG068192
6 · The paper itself

Abstract

objectiveTo identify differences in multimorbidity and individual comorbidities among individuals with rheumatoid arthritis (RA), separated by race and ethnicity.

methodsThis case-control study within OptumLabs Data Warehouse from 2010 to 2019 matched RA cases (defined by 2 codes plus prescription of an RA drug) to non-RA controls 1:1 on age, sex, race and ethnicity, region, index date of RA, and insurance coverage duration. We defined multimorbidity as the presence of ≥2 or ≥5 validated comorbidities. Logistic regression models calculated adjusted odds of multimorbidity with 95% confidence intervals (95% CIs) within each race and ethnicity.

resultsWe identified 154,391 RA cases and 154,391 controls (mean age 59.6, 76% female). Black enrollees had the most multimorbidity ≥2/≥5 (73.1%, 34.3%); Asian enrollees had the least (52.4%, 17.3%). Adjusted odds of multimorbidity ≥2 and ≥5 in RA cases versus controls was 2.19 (95% CI 2.16-2.23) and 2.06 (95% CI 2.02-2.09), respectively. This increase was similar across race and ethnicity. However, we observed elevated occurrence of certain comorbidities by race and ethnicity versus controls (P < 0.001), including renal disease in White enrollees (4.7% versus 3.2%) and valvular heart disease in Black and White enrollees (3.2% and 2.8% versus 2.6% and 2.2%).

conclusionMultimorbidity is a problem for all RA patients. Targeted identification of certain comorbidities by race and ethnicity may be a helpful approach to mitigate multimorbidity.

Indexed as

Arthritis, RheumatoidMultimorbidityCase-Control StudiesComorbidityFemaleHumansMaleMiddle AgedRace Factors

Identifiers

PMID36094853
PMCPMC9797440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.