ArticleMolecular plant pathology2022
Naringenin confers defence against Phytophthora nicotianae through antimicrobial activity and induction of pathogen resistance in tobacco.
Article in Molecular plant pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Flavonoids as Antimicrobial Pesticides: Mechanisms of Action, Formulation Strategies, and Perspectives for Pre- and Postharvest Disease Management.Plants (Basel, Switzerland) · 2026Review
- Histone demethylase CsJMJ12 enhances resistance of Navel orange to Penicillium digitatum via H3K27me3 demethylation.Journal of advanced research · 2026Article
- Dual functions of apigenin in suppressing Phytophthora capsici and shaping the pepper microbiome.Microbiome · 2026Article
- Dual impact of ambient pH on the virulence of Phytophthora nicotianae and resistance in tobacco.Plant cell reports · 2026Article
- Water Limitation Causes Early-Stage Metabolic Perturbation in the Interaction of Soybean and Asian Soybean Rust.Journal of agricultural and food chemistry · 2026Article
- Molecular Interactions Between Soil-Borne Oomycetes and Plants: Infection Mechanisms, Host Resistance, and Implications for Sustainable Agriculture.Plants (Basel, Switzerland) · 2026Review
- Priming of plant innate immunity by β-aminobutyric acid improved barley resistance to grain aphid (Sitobion avenae).BMC plant biology · 2026Article
- Integrated transcriptomic and proteomic analysis reveals inhibitory effects of naringenin application on soybean roots mainly by interfering with auxin and ROS concentrations.BMC plant biology · 2026Article
- Isolation, identification, and antimicrobial effect analysis of active components fromFrontiers in plant science · 2026Article
- Phenylalanine Ammonia-Lyase: A Core Regulator of Plant Carbon Metabolic Flux Redistribution-From Molecular Mechanisms and Growth Modulation to Stress Adaptability.Plants (Basel, Switzerland) · 2025Review
- Silica nanoparticles suppress fungal pathogenic allies to alleviate Astragalus root rot.Microbiome · 2025Article
- Metabolome integrated with transcriptome, and genome analysis revealed higher accumulations of phytoalexins enhance resistance against Magnaporthe oryzae in new Zhefang rice variety diantun 506.BMC plant biology · 2025Article
- Elicitor Specific Mechanisms of Defence Priming in Oak Seedlings Against Powdery Mildew.Plant, cell & environment · 2025Article
- Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period.BMC plant biology · 2025Article
- Metabolomic analyses reveal that graphene oxide alleviates nicosulfuron toxicity in sweet corn.Frontiers in plant science · 2025Article
- Quasi-targeted metabolomics revealed isoliquiritigenin and lauric acid associated with resistance to tobacco black shank.Plant signaling & behavior · 2024Article
- The Preliminary Analysis of Flavonoids in the Petals ofInternational journal of molecular sciences · 2024Article
- Naringenin restricts the colonization and growth of Ralstonia solanacearum in tobacco mutant KCB-1.Plant physiology · 2024Article
- PlAtg8-mediated autophagy regulates vegetative growth, sporangial cleavage, and pathogenesis inMicrobiology spectrum · 2024Article
- Therapeutic Effect and Safety Evaluation of Naringin onInternational journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco black shank caused by Phytophthora nicotianae is a serious disease in tobacco cultivation. We found that naringenin is a key factor that causes different sensitivity to P. nicotianae between resistant and susceptible tobacco. The level of basal flavonoids in resistant tobacco was distinct from that in susceptible tobacco. Of all flavonoids with different content, naringenin showed the best antimicrobial activity against mycelial growth and sporangia production of P. nicotianae in vitro. However, naringenin showed very low or no antimicrobial activity to other plant pathogens. We found that naringenin induced not only the accumulation of reactive oxygen species, but also the expression of salicylic acid biosynthesis-related genes. Naringenin induced the expression of the basal pathogen resistance gene PR1 and the SAR8.2 gene that contributes to plant resistance to P. nicotianae. We then interfered with the expression of the chalcone synthase (NtCHS) gene, the key gene of the naringenin synthesis pathway, to inhibit naringenin biosynthesis. NtCHS-RNAi rendered tobacco highly sensitive to P. nicotianae, but there was no change in susceptibility to another plant pathogen, Ralstonia solanacearum. Finally, exogenous application of naringenin on susceptible tobacco enhanced resistance to P. nicotianae and naringenin was very stable in this environment. Our findings revealed that naringenin plays a core role in the defence against P. nicotianae and expanded the possibilities for the application of plant secondary metabolites in the control of P. nicotianae.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.