Evidence map›Paper›PMID 36094467›Full record

ArticleHuman vaccines & immunotherapeutics2022

Correlation between anti-S IgG and neutralizing antibody titers against three live SARS-CoV-2 variants in BNT162b2 vaccine recipients.

Yuki Higashimoto, Kei Kozawa, Hiroki Miura, Yoshiki Kawamura, Masaru Ihira, Hiroyuki Hiramatsu, Ryota Suzuki, Kei Haga, Reiko Takai-Todaka, Akihito Sawada and 2 more

Open access · goldAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yuki HigashimotoFaculty of Medical Technology, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.ORCID 0000-0002-1794-9736
Kei KozawaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Hiroki MiuraDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Yoshiki KawamuraDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Masaru IhiraFaculty of Clinical Engineering, Fujita Health University School of Medical Sciences, Toyoake, Aichi, Japan.
Hiroyuki HiramatsuDepartment of Clinical Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Ryota SuzukiDepartment of Clinical Pharmacy, Fujita Health University Hospital, Toyoake, Aichi, Japan.
Kei HagaLaboratory of Viral Infection Control, Department of Infection Control Science and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Reiko Takai-TodakaLaboratory of Viral Infection Control, Department of Infection Control Science and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Akihito SawadaLaboratory of Viral Infection Control, Department of Infection Control Science and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Kazuhiko KatayamaLaboratory of Viral Infection Control, Department of Infection Control Science and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Fujita Health University · JPKitasato University · JPFujita Health University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed serially collected serum samples from healthy adults who underwent BNT162b2 vaccination to elucidate the association between spike (S)-IgG antibody titers determined by ELISA using the WHO international standard (NIBSC code 20/136) and neutralizing antibody titers against three live SARS-CoV-2 variants. This study included 53 health care workers who received two doses of the BNT162b2 vaccine. S-IgG and nucleocapsid (N)-IgG antibody titers were measured by ELISA. Neutralizing (NT) antibody responses against three variants (Wuhan D614 G: KUH003, Alpha, and Delta) were evaluated before and after the first and second vaccination.

Indexed as

COVID-19VaccinesAdultAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineHumansImmunoglobulin GSARS-CoV-2VaccinationAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineImmunoglobulin GVaccinesCOVID-19ELISAneutralizing antibodySARS-CoV-2

Identifiers

PMID36094467
PMCPMC9746447
OpenAlexW4296554159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.