Evidence map›Paper›PMID 36094216›Full record

ArticleAntimicrobial agents and chemotherapy2022

Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.

Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K Tumwebaze, Oswald Byaruhanga, Martin Okitwi, Stephen Orena, Thomas Katairo, Samuel L Nsobya, Melissa D Conrad and 10 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Ubiquitin-proteasome system inFrontiers in medicine · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 3 countries.

Shreeya GargDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.
Oriana KreutzfeldDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0003-2026-345X
Sevil ChelebievaDepartment of Natural Sciences and Mathematics, Dominican University of Californiagrid.255148.f, San Rafael, California, USA.
Patrick K TumwebazeInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Martin OkitwiInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Stephen OrenaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Thomas KatairoInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Samuel L NsobyaInfectious Diseases Research Collaborationgrid.463352.5, Kampala, Uganda.
Melissa D ConradDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-9984-8030
Ozkan AydemirProgram in Molecular Medicine, University of Massachusetts, Worcester, Massachusetts, USA.
Jennifer LegacDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.
Alexandra E GouldTakeda Pharmaceuticals, Cambridge, Massachusetts, USA.
Brett R BaylesDepartment of Natural Sciences and Mathematics, Dominican University of Californiagrid.255148.f, San Rafael, California, USA.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown Universitygrid.40263.33, Providence, Rhode Island, USA.
Maelle DuffeyMedicines for Malaria Venture, Geneva, Switzerland.
Gang LinDepartment of Microbiology and Immunology, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Laura A KirkmanDepartment of Microbiology and Immunology, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.ORCID 0000-0003-4085-5540
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of Californiagrid.255148.f, San Rafael, California, USA.ORCID 0000-0002-8437-9382
Philip J RosenthalDepartment of Medicine, University of California, San Franciscogrid.266102.1, California, USA.ORCID 0000-0002-7953-7622
Infectious Diseases Research Collaboration · UGUniversity of California, San Francisco · USDominican University of California · USCornell University · USBrown University · USMedicines for Malaria Venture · CHTakeda (United States) · USUniversity of Massachusetts Chan Medical School · US

Funding

Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarialsR01AI143714 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Gang Lin · 2019 to 2026
$6.1M
Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618k
HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD) T37MD003407HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (DMID) AI075045HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (DMID) AI139179HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (DMID) AI143714NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139179NIAID NIH HHS R01 AI143714NIAID NIH HHS R56 AI075045
6 · The paper itself

Abstract

The proteasome is a promising target for antimalarial chemotherapy. We assessed

Indexed as

AntimalarialsPlasmodium falciparumProteasome InhibitorsAsparagineDrug ResistanceEthylenediaminesHumansMalaria, FalciparumPeptidesProteasome Endopeptidase ComplexSulfonesUgandaAntimalarialsAsparaginedivinyl sulfoneEthylenediaminesPeptidesProteasome Endopeptidase ComplexProteasome InhibitorsSulfonesantimalarial agentsPlasmodium falciparumproteasome

Identifiers

PMID36094216
PMCPMC9578402
OpenAlexW4295279296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.