Evidence map›Paper›PMID 36094199›Full record

ArticleAntimicrobial agents and chemotherapy2022

A Cephalosporin-Tripodalamine Conjugate Inhibits Metallo-β-Lactamase with High Efficacy and Low Toxicity.

Hongyan Tian, Yiwan Wang, Yang Dai, Anwen Mao, Wanqing Zhou, Xiaoli Cao, Hui Deng, Hao Lu, Lin Ding, Han Shen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hongyan Tian *Institute of Advanced Synthesis, Institute of Chemical Biology and Functional Molecules, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Yiwan Wang *Institute of Advanced Synthesis, Institute of Chemical Biology and Functional Molecules, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.
Yang Dai *Department of Geriatrics, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Anwen MaoState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing Universitygrid.41156.37, Nanjing, China.
Wanqing ZhouDepartment of Laboratory Medicine, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Xiaoli CaoDepartment of Laboratory Medicine, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Hui DengDepartment of Geriatrics, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Hao LuDepartment of Geriatrics, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Lin DingState Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing Universitygrid.41156.37, Nanjing, China.
Han ShenDepartment of Laboratory Medicine, Nanjing Drum Tower Hospitalgrid.428392.6, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Xiaojian WangInstitute of Advanced Synthesis, Institute of Chemical Biology and Functional Molecules, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, China.ORCID 0000-0002-1502-8781
Nanjing Drum Tower Hospital · CNNanjing Tech University · CNNanjing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wide spread of metallo-β-lactamase (MBL)-expressing bacteria has greatly threatened human health, and there is an urgent need for inhibitors against MBLs. Herein, we present a cephalosporin-tripodalamine conjugate (DPASC) as a potent MBL inhibitor with a block-release design. The cephalosporin tag blocks the ligand binding site to reduce toxicity and is cleaved by MBLs to release active ligands to inhibit MBLs

Indexed as

beta-LactamasesCephalosporinsAnti-Bacterial Agentsbeta-Lactamase InhibitorsHumansLigandsMeropenemMicrobial Sensitivity TestsMonobactamsAnti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-LactamasesCephalosporinsLigandsMeropenemMonobactamsbacterial infectioncephalosporin conjugateinhibitormetallo-beta-lactamaseself-immolative linkage

Identifiers

PMID36094199
PMCPMC9578398
OpenAlexW4295281064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.