Evidence map›Paper›PMID 36094170›Full record

ArticleeLife2022

The acid ceramidase/ceramide axis controls parasitemia in

Anne Günther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Anne GüntherInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Matthias HoseInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID 0000-0003-0746-5591
Hanna AbbergerInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Fabian SchumacherInstitute of Pharmacy, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0001-8703-3275
Ylva VeithMolecular Parasitology, Institute of Biology/Faculty for Life Sciences, Humboldt University Berlin, Berlin, Germany.
Burkhard KleuserInstitute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Kai MatuschewskiMolecular Parasitology, Institute of Biology/Faculty for Life Sciences, Humboldt University Berlin, Berlin, Germany.ORCID 0000-0001-6147-8591
Karl Sebastian LangInstitute of Immunology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Erich GulbinsInstitute of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
Jan BuerInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-7602-1698
Astrid M WestendorfInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-2121-2892
Wiebke HansenInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-6020-0886
University of Duisburg-Essen · DECal Poly Humboldt · USFreie Universität Berlin · DEInstitute of Immunology · HRInstitute of Molecular Biology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity and ceramide on the course of

Indexed as

MalariaPlasmodium yoeliiAcid CeramidaseAnimalsCeramidesErythropoiesisMiceParasitemiaAcid CeramidaseCeramidesceramideinfectious diseasemalariamicrobiologymousesphingolipids

Identifiers

PMID36094170
PMCPMC9499531
OpenAlexW4295292842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.