Evidence map›Paper›PMID 36094141›Full record

ArticleThe oncologist2022

Access to and Affordability of World Health Organization Essential Medicines for Cancer in Sub-Saharan Africa: Examples from Kenya, Rwanda, and Uganda.

Darya A Kizub, Sachin Naik, Ayokunle A Abogan, Debanjan Pain, Stephen Sammut, Lawrence N Shulman, Yehoda M Martei

Open access · goldAbstract read
In one paragraph

Article in The oncologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Darya A KizubDepartment of General Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7925-2785
Sachin NaikHarvard Medical School, Boston, MA, USA.
Ayokunle A AboganClinton Health Access Initiative, Boston, MA, USA.
Debanjan PainDepartment of Medicine (Hematology-Oncology), University of Pennsylvania, Philadelphia, PA, USA.
Stephen SammutDepartment of Health Care Management, Wharton School, University of Pennsylvania, Philadelphia, PA, USA.
Lawrence N ShulmanDepartment of Medicine (Hematology-Oncology), University of Pennsylvania, Philadelphia, PA, USA.
Yehoda M MarteiDepartment of Medicine (Hematology-Oncology), University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USClinton Health Access Initiative · USHarvard University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Fidelity and adaptation of breast cancer resource-stratified treatment guidelines in BotswanaK01TW011481 · FIC · UNIVERSITY OF PENNSYLVANIA · PI MARTEI, YEHODA MARTEKI · 2020 to 2023
$548k
FIC NIH HHS K01 TW011481
6 · The paper itself

Abstract

backgroundCancer mortality is high in sub-Saharan Africa (SSA), partly due to inadequate treatment access. We explored access to and affordability of cancer treatment regimens for the top 10 cancers utilizing examples from Kenya, Uganda, and Rwanda. MATERIALS AND

methodsPopulation, healthcare financing, minimum wage, and cancer incidence and mortality data were obtained from the WHO, World Bank, public sources, and GLOBOCAN. National Essential Medicines List (NEML) alignment with 2019 WHO EML was assessed as a proportion. Cancer regimen pricing was calculated using public and proprietary sources and methods from prior studies. Affordability through universal healthcare coverage (UHC) was assessed as 1-year cost <3× gross national income per capita; and to patients out-of-pocket (OOP), as 30-day treatment course cost <1 day of minimum wage work.

resultsA total of 93.4% of the WHO EML cancer medicines were listed on the 2019 Kenya NEML, and 70.5% and 41.1% on Uganda (2016) and Rwanda (2015) NEMLs, respectively. Generic chemotherapies were available and affordable to governments through UHC to treat non-Hodgkin's lymphoma, cervical, breast, prostate, colorectal, ovarian cancers, and select leukemias. Newer targeted agents were not affordable through government UHC purchasing, while some capecitabine-based regimens were not affordable in Uganda and Rwanda. All therapies were not affordable OOP.

conclusionAll cancer treatment regimens were not affordable OOP and some were not covered by governments. Newer targeted drugs were not affordable to all 3 governments. UHC of cancer drugs and improving targeted therapy affordability to LMIC governments in SSA are key to improving treatment access and health outcomes.

Indexed as

Drugs, EssentialNeoplasmsCosts and Cost AnalysisHealth Services AccessibilityHumansKenyaRwandaUgandaWorld Health OrganizationDrugs, Essentialantineoplastic agentscosts and cost analysishealthcare financingKenyaRwandaUganda

Identifiers

PMID36094141
PMCPMC9632308
OpenAlexW4295279253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.