Evidence map›Paper›PMID 36094114›Full record

ArticlemBio2022

Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis.

Romana R Gerner, Suzana Hossain, Artur Sargun, Kareem Siada, Grant J Norton, Tengfei Zheng, Wilma Neumann, Sean-Paul Nuccio, Elizabeth M Nolan, Manuela Raffatellu

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  19. The Diversity ofMicroorganisms · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Romana R GernerDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-2377-6509
Suzana HossainDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.
Artur SargunDepartment of Chemistry, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Kareem SiadaDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.
Grant J NortonDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.
Tengfei ZhengDepartment of Chemistry, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Wilma NeumannDepartment of Chemistry, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.
Sean-Paul NuccioDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-9683-9278
Elizabeth M NolanDepartment of Chemistry, Massachusetts Institute of Technologygrid.116068.8, Cambridge, Massachusetts, USA.ORCID 0000-0002-6153-8803
Manuela RaffatelluDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-6487-4215
University of California San Diego · USMassachusetts Institute of Technology · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1M
Harnessing iron acquisition to hinder enterobacterial pathogenesisR01AI176390 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth M Nolan, Manuela Raffatellu · 2023 to 2026
$2.9M
Nutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9M
Development of siderophore-based vaccines against non-typhoidal Salmonella infectionR01AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2015 to 2019
$1.9M
Nutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8M
Antimicrobial activity of Escherichia coli Nissle 1917 microcin MR21AI154644 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2020 to 2021
$440k
Harnessing iron acquisition to hinder enterobacterial pathogenesisR56AI114625 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2022 to 2022
$400k
NIAID NIH HHS R01 AI114625NIAID NIH HHS R01 AI126277NIAID NIH HHS R01 AI145325NIAID NIH HHS R01 AI176390NIAID NIH HHS R21 AI154644NIAID NIH HHS R37 AI126277NIAID NIH HHS R56 AI114625NIDDK NIH HHS T32 DK007202NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the gastrointestinal tract and profound alterations to the gut microbiome. Adherent-invasive Escherichia coli (AIEC) is a mucosa-associated pathobiont that colonizes the gut of patients with Crohn's disease, a form of IBD. Because AIEC exacerbates gut inflammation, strategies to reduce the AIEC bloom during colitis are highly desirable. To thrive in the inflamed gut,

Indexed as

ColitisCrohn DiseaseEscherichia coli InfectionsInflammatory Bowel DiseasesAnimalsAnti-Bacterial AgentsAntibodies, MonoclonalBacterial AdhesionCholera ToxinDextran SulfateEnterobactinEscherichia coliImmunizationInflammationInterleukin-10Intestinal MucosaAnti-Bacterial AgentsAntibodies, MonoclonalCholera ToxinDextran SulfateEnterobactinInterleukin-10IronMicronutrientsSiderophoresEscherichia coligut inflammationimmunizationinflammatory bowel diseaseiron utilizationmucosal immunitysiderophores

Identifiers

PMID36094114
PMCPMC9600343
OpenAlexW4295290408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.