Evidence map›Paper›PMID 36093880›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis,

Mohamed H Saad, Tarek F El-Moselhy, Nabaweya S El-Din, Ahmed B M Mehany, Amany Belal, Mohammed A S Abourehab, Haytham O Tawfik, Mervat H El-Hamamsy

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Click synthesis of some novel benzo[RSC medicinal chemistry · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. NovelJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed H SaadThe Egyptian Ministry of Health, Tanta, Egypt.
Tarek F El-MoselhyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Nabaweya S El-DinDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Ahmed B M MehanyZoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-9913-5380
Amany BelalMedicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.ORCID 0000-0003-1045-0163
Mohammed A S AbourehabDepartment of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0003-1348-6567
Haytham O TawfikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.ORCID 0000-0001-6455-5716
Mervat H El-HamamsyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new series of symmetric (

Indexed as

Antineoplastic AgentsNitrilesATP Binding Cassette Transporter, Subfamily BDihydropyridinesHumansMolecular Docking SimulationStructure-Activity Relationship1,4-dihydropyridineAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BDihydropyridinesNitriles1,4-DHPsanticancerantimicrobialapoptosismultidrug resistance (MDR)P-glycoproteinreceptor tyrosine kinases (RTKs)

Identifiers

PMID36093880
PMCPMC9481151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.