Evidence map›Paper›PMID 36093849›Full record

ArticleJournal of veterinary internal medicine2022

Neurological disease suspected to be caused by tick-borne encephalitis virus infection in 6 horses in Switzerland.

Ioannis Magouras, Angelika Schoster, Nathalie Fouché, Vinzenz Gerber, Martin H Groschup, Ute Ziegler, Raffael Fricker, Christian Griot, Andrea Vögtlin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 5 countries.

Ioannis MagourasVeterinary Public Health Institute, Department of Clinical Research and Veterinary Public Health, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-9282-8512
Angelika SchosterClinic for Equine Internal Medicine, Equine Department, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-2162-6550
Nathalie FouchéSwiss Institute of Equine Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-4323-1645
Vinzenz GerberSwiss Institute of Equine Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7834-4482
Martin H GroschupInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald, Insel Riems, Germany.
Ute ZieglerInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald, Insel Riems, Germany.
Raffael FrickerInstitute for Virology and Immunology IVI, Department of Infectious Diseases and Pathobiology, University of Bern, Mittelhäusern and Bern, Switzerland.
Christian GriotInstitute for Virology and Immunology IVI, Department of Infectious Diseases and Pathobiology, University of Bern, Mittelhäusern and Bern, Switzerland.
Andrea VögtlinInstitute for Virology and Immunology IVI, Department of Infectious Diseases and Pathobiology, University of Bern, Mittelhäusern and Bern, Switzerland.
University of Bern · CHFriedrich-Loeffler-Institut · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReports on acute tick-borne encephalitis virus (TBEV) infections with signs of neurologic disease in horses are limited.

objectivesTo describe the epidemiological, clinical, and laboratory findings of suspected acute TBEV infections in 6 horses. ANIMALS: Six horses originating from TBEV endemic regions of Switzerland were presented to equine hospitals with acute onset of neurologic disease between 2011 and 2019.

methodsRetrospective case series. Horses with acute onset of signs of neurologic disease that were subjected to clinical and microbiological examinations to rule out infectious diseases affecting the central nervous system.

resultsAll horses exhibited acute signs of neurologic disease including ataxia and proprioceptive deficits. Horses tested positive for TBEV using virus neutralization test and samples were further tested for TBEV-specific IgM. The presence of TBEV-specific IgM antibodies was confirmed in 5 horses (cases 1-5, Laboratory Unit [LU] values ranging from 30 to 56). One horse (case no. 6) with an LU value just below the test threshold (LU = 22.3) was also included under the hypothesis that the horse was transitioning from acute to chronic infection. All horses originated from areas where humans with confirmed tick-borne encephalitis reported to have been bitten by ticks. CONCLUSIONS AND CLINICAL IMPORTANCE: Acute TBEV infection should be a differential diagnosis in horses with signs of neurologic disease and originating from TBEV endemic areas. The establishment of harmonized diagnostic criteria would help to overcome the diagnostic challenges associated with TBEV and other Flavivirus infections in horses.

Indexed as

Encephalitis Viruses, Tick-BorneFlavivirus InfectionsHorse DiseasesAnimalsAntibodies, ViralHorsesHumansImmunoglobulin MRetrospective StudiesSwitzerlandAntibodies, ViralImmunoglobulin Mataxiaflavivirusmeningoencephalitisticksvector-borne

Identifiers

PMID36093849
PMCPMC9708414
OpenAlexW4295261501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.