ArticleHypertension (Dallas, Tex. : 1979)2022
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Chronobiology of meal timing in early-stage hypertension: a controlled feeding pilot study investigating the effects on renal and vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Dietary salt impairs circadian physiological metabolic adaptations in salt-sensitive hypertension.Function (Oxford, England) · 2026Article
- Circadian physiology changes with aging: age is just a number, but circadian physiology keeps time.Current opinion in physiology · 2026Article
- Opportunities for RNA sequencing in physiology: from big data to understanding homeostasis and heterogeneity.Function (Oxford, England) · 2026Review
- Review
- Neurobiology of the circadian clock and its role in cardiovascular disease: Mechanisms, biomarkers, and chronotherapy.Neurobiology of sleep and circadian rhythms · 2025Review
- Null mutation of the p67phox subunit of NOX2 permits compensatory changes in renal blood flow during the development of salt-sensitive hypertension in SS rats.American journal of physiology. Renal physiology · 2025Article
- Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Integrative Bioinformatics-Guided Analysis of Glomerular Transcriptome Implicates Potential Therapeutic Targets and Pathogenesis Mechanisms in IgA Nephropathy.Bioengineering (Basel, Switzerland) · 2025Article
- Endothelin-1 signaling in the kidney: recent advances and remaining gaps.American journal of physiology. Renal physiology · 2025Review
- Radiation-Induced Cardiotoxicity in Hypertensive Salt-Sensitive Rats: A Feasibility Study.Life (Basel, Switzerland) · 2025Article
- A novel automated method for comprehensive renal cast quantification from rat kidney sections using QuPath.American journal of physiology. Renal physiology · 2025Article
- Research progress on the role and mechanism of circadian clock geneFrontiers in immunology · 2025Review
- A comparative transcriptomics analysis of mammalian and non-mammalian acute kidney injury (AKI) models.Frontiers in cell and developmental biology · 2025Article
- Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.American journal of physiology. Renal physiology · 2025Article
- Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.The Journal of biological chemistry · 2024Article
- Article
- Research progress of circadian rhythm in cardiovascular disease: A bibliometric study from 2002 to 2022.Heliyon · 2024Review
- Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundCircadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mice show that PER1 plays a role in the regulation of blood pressure and renal sodium handling; however, the results are dependent on the strain being studied. Using male Dahl salt-sensitive (SS) rats with global knockout of PER1 (SS
methodsThe model was generated using CRISPR/Cas9 and was characterized using radiotelemetry and measures of renal function and circadian rhythm.
resultsSS
conclusionsAltogether, our findings demonstrate that loss of PER1 in Dahl SS rats causes an array of deleterious effects, including exacerbation of the development of salt-sensitive hypertension and renal damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.